Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm

Theophilus I. Emeto; Faith O. Alele; Amy M. Smith; Felicity M. Smith; Tammy Dougan; Jonathan Golledge

doi:10.3389/fcvm.2017.00016

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Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm

Journal article

Open access

Peer reviewed

Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm

Theophilus I. Emeto, Faith O. Alele, Amy M. Smith, Felicity M. Smith, Tammy Dougan and Jonathan Golledge

Frontiers in Cardiovascular Medicine, Vol.4, pp.1-10

2017

DOI: https://doi.org/10.3389/fcvm.2017.00016

PMCID: PMC5362602

PMID: 28386544

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Abstract

abdominal aortic aneurysm

nanoparticles

diagnosis

human studies

animal studies

Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA. Currently, ultrasmall superparamagnetic NPs enhanced magnetic resonance imaging appears to hold the greatest potential for imaging macrophage-mediated inflammation in human AAA.

Details

Title: Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
Authors: Theophilus I. Emeto (Corresponding Author) - James Cook University
Faith O. Alele (Author) - James Cook University
Amy M. Smith (Author) - James Cook University
Felicity M. Smith (Author) - James Cook University
Tammy Dougan (Author) - Addenbrooke's Hospital
Jonathan Golledge (Author) - Townsville Hospital
Publication details: Frontiers in Cardiovascular Medicine, Vol.4, pp.1-10
Publisher: Frontiers Research Foundation
Date published: 2017
DOI: 10.3389/fcvm.2017.00016
ISSN: 2297-055X
PMID: 28386544; PMC5362602
Copyright note: Copyright © 2017 Emeto, Alele, Smith, Smith, Dougan and Golledge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Grants: Assessment of the efficacy of a brief behaviour intervention designed to improve physical activity in patients with peripheral artery disease, 1063476 , National Health and Medical Research Council (Australia, Canberra) - NHMRC
Developing improved management for peripheral artery diseases, 1117061, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: JG: NHMRC 1098717; 1079369; 1079193; 1022752
Organisation Unit: School of Health - Public Health
Language: English
Record Identifier: 99967697402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems

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