Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease

Belinda J. Parmenter; Mary M. Kavurma; Toby Richards; Clare Arnott; Sarah J. Aitken; Steven G. Wise; Michael P. Gray; Jonathan Golledge; Christopher D. Askew; Shreeya Smith; Alexis Hure; Gemma A. Figtree; Australian Cardiovascular Alliance National Peripheral Artery Disease Working Group

doi:10.1016/j.hlc.2024.12.007

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Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease

Journal article

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Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease

Belinda J. Parmenter, Mary M. Kavurma, Toby Richards, Clare Arnott, Sarah J. Aitken, Steven G. Wise, Michael P. Gray, Jonathan Golledge, Christopher D. Askew, Shreeya Smith, …

Heart, Lung and Circulation, Vol.34(3), pp.225-234

2025

DOI: https://doi.org/10.1016/j.hlc.2024.12.007

PMID: 39919990

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Abstract

Peripheral artery disease

Peripheral vascular disease

Peripheral arterial disease (PAD) is characterised by atherosclerotic stenosis or occlusion of arteries that leads to reduced blood flow to the limbs. PAD is associated with a very high rate of cardiovascular morbidity and mortality making the health and economic burden of PAD substantial. Despite high-quality evidence and international guidelines recommending conservative medical management of risk factors, and exercise and lifestyle interventions, surgical revascularisation (open or endovascular) remains the main treatment for PAD. Alarmingly, up to one-third of patients do not receive best medical therapy after revascularisation surgery despite evidence supporting this treatment reduces cardiovascular events. Due to the considerable health burden that PAD presents, this manuscript aims to identify gaps in care and clinical research in PAD across Australia and proposes potential collaborative solutions. In Australia, there is significant disparity in care between rural/regional and metropolitan communities. These gaps are exacerbated by inequitable access to services across Australia, particularly for First Nation Australians, culturally and linguistically diverse groups and those living in regional and remote areas. This review identifies unmet needs for patients with PAD that are multifaceted, spanning from improved understanding of disease mechanisms, diagnostic tools for risk stratification and personalised therapy, to a paucity of medical and rehabilitation therapies for symptoms or prevention of cardiovascular complications. Furthermore, there are opportunities for national and international registries to optimise clinical trial quality and outcomes. Strategies should be applied to improve implementation of optimal medical therapy in PAD which will improve quality of life, reduce health care costs, and prevent secondary complications, limb loss, and mortality across Australia’s diverse population.

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Title: Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease
Authors: Belinda J. Parmenter (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise Science
Mary M. Kavurma - The Heart Research Institute
Toby Richards - University of East London
Clare Arnott - The George Institute for Global Health, Faculty of Medicine & Health, UNSW Sydney, Sydney, NSW, Australia
Sarah J. Aitken - The Heart Research Institute
Steven G. Wise - The University of Sydney
Michael P. Gray - The University of Sydney
Jonathan Golledge - James Cook University
Christopher D. Askew - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise Science
Shreeya Smith - Western Sydney University
Alexis Hure - University of Newcastle Australia
Gemma A. Figtree - The University of Sydney
Australian Cardiovascular Alliance National Peripheral Artery Disease Working Group (Research Group)
Publication details: Heart, Lung and Circulation, Vol.34(3), pp.225-234
Publisher: Elsevier Australia
Date published: 2025
DOI: 10.1016/j.hlc.2024.12.007
ISSN: 1444-2892; 1443-9506
PMID: 39919990
Copyright note: 2024 The Author(s). Published by Elsevier B.V. on behalf of Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: Healthy Ageing Research Cluster; Cancer Research Cluster; School of Health - Sports & Exercise Science
Language: English
Record Identifier: 991112352302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems

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