Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

Casey Paquola; Maxwell Bennett; Jim Lagopoulos

doi:10.1016/j.neubiorev.2016.08.011

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Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

Journal article

Peer reviewed

Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

Casey Paquola, Maxwell Bennett and Jim Lagopoulos

Neuroscience and Biobehavioral Reviews, Vol.69, pp.299-312

2016

DOI: https://doi.org/10.1016/j.neubiorev.2016.08.011

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

childhood trauma

abuse

grey matter

hippocampus

amygdala

voxel based morphometry

psychiatric diagnosis

UniSC Diversity Area - Life Stages

Childhood trauma has been associated with long term effects on prefrontal-limbic grey matter. A literature search was conducted to identify structural magnetic resonance imaging studies of adults with a history of childhood trauma. We performed three meta-analyses. Hedges' g effect sizes were calculated for each study providing hippocampal or amygdala volumes of trauma and non-trauma groups. Seed based differential mapping was utilised to synthesise whole brain voxel based morphometry (VBM) studies. A total of 38 articles (17 hippocampus, 13 amygdala, 19 whole brain VBM) were included in the meta-analyses. Trauma cohorts exhibited smaller hippocampus and amygdala volumes bilaterally. The most robust findings of the whole brain VBM meta-analysis were reduced grey matter in the right dorsolateral prefrontal cortex and right hippocampus amongst adults with a history of childhood trauma. Subgroup analyses and meta-regressions showed results were moderated by age, gender, the cohort's psychiatric health and the study's definition of childhood trauma. We provide evidence of abnormal grey matter in prefrontal-limbic brain regions of adults with a history of childhood maltreatment.

Details

Title: Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review
Authors: Casey Paquola (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Jim Lagopoulos (Author) - University of the Sunshine Coast
Publication details: Neuroscience and Biobehavioral Reviews, Vol.69, pp.299-312
Publisher: Pergamon
Date published: 2016
DOI: 10.1016/j.neubiorev.2016.08.011
ISSN: 0149-7634
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450572602621
Output Type: Journal article

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Web Of Science research areas: Behavioral Sciences; Neurosciences

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