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Published VersionCC BY V4.0, Open Access
Journal article
Understanding Wellbeing Profiles According to White Matter Structural Connectivity Sub-types in Early Adolescents: The First Hundred Brains Cohort from the Longitudinal Adolescent Brain Study
Journal of Youth and Adolescence, Vol.53, pp.1029-1046
2024
PMID: 38217837
Appears in Thompson Institute Research Collection
Abstract
Wellbeing is protective against the emergence of psychopathology. Neurobiological markers associated with mental wellbeing during adolescence are important to understand. Limited research has examined neural networks (white matter tracts) and mental wellbeing in early adolescence specifically. A cross-sectional diffusion tensor imaging analysis approach was conducted, from the Longitudinal Adolescent Brain study, First Hundred Brains cohort (N = 99; 46.5% female; M = 13.01, SD = 0.55). Participants completed self-report measures including wellbeing, quality-of-life, and psychological distress. Potential neurobiological profiles using fractional anisotropy, axial, and radial diffusivity were determined via a whole brain voxel-wise approach, and hierarchical cluster analysis of fractional anisotropy values, obtained from 21 major white matter tracts. Three cluster groups with significantly different neurobiological profiles were distinguished. No significant differences were found between the three cluster groups and measures of wellbeing, but two left lateralized significant associations between white matter tracts and wellbeing measures were found. These results provide preliminary evidence for potential neurobiological markers of mental health and wellbeing in early adolescence and should be tracked longitudinally to provide more detailed and robust findings.
Details
- Title
- Understanding Wellbeing Profiles According to White Matter Structural Connectivity Sub-types in Early Adolescents: The First Hundred Brains Cohort from the Longitudinal Adolescent Brain Study
- Authors
- Christina Driver (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAmanda Boyes (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAbdalla Z Mohamed (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJacob M Levenstein (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMarcella Parker (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Journal of Youth and Adolescence, Vol.53, pp.1029-1046
- Publisher
- Springer New York LLC
- Date published
- 2024
- DOI
- 10.1007/s10964-024-01939-2
- ISSN
- 1573-6601; 0047-2891
- PMID
- 38217837
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Grant note
- Prioritizing Mental Health Initiative, Australian Commonwealth Government.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99992697802621
- Output Type
- Journal article
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