Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus

K M Klassen; C K Fairley; Michael G Kimlin; M Kelly; T R H Read; J Broom; D B Russell; P R Ebeling

doi:10.1111/php.12390

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Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus

Journal article

Peer reviewed

Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus

K M Klassen, C K Fairley, Michael G Kimlin, M Kelly, T R H Read, J Broom, D B Russell and P R Ebeling

Photochemistry and Photobiology, Vol.91(2), pp.431-437

2015

DOI: https://doi.org/10.1111/php.12390

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Abstract

human immunodeficiency virus

This study aimed to document the vitamin D status of HIV-infected individuals across a wide latitude range in one country and to examine associated risk factors for low vitamin D. Using data from patients attending four HIV specialist clinics across a wide latitude range in Australia, we constructed logistic regression models to investigate risk factors associated with 25(OH)D < 75 nmol L-1. 1788 patients were included; 87% were male, 76% Caucasian and 72% on antiretroviral therapy. The proportion with 25(OH)D < 50 nmol L-1 was 27%, and <75 nmol L-1 was 54%. Living in Melbourne compared with Cairns (adjusted odds ratio (aOR) 3.30; 95% CI 2.18, 4.99, P < 0.001) and non-Caucasian origin (aOR 2.82, 95% CI 2.12, 3.75, P < 0.001) was associated with an increased risk, while extreme UV index compared with low UV index was associated with a reduced risk (aOR 0.33; 95% CI 0.20, 0.55, P < 0.001) of 25(OH)D < 75 nmol L-1. In those with biochemistry available (n = 1117), antiretroviral therapy was associated with 25(OH)D < 75 nmol L-1; however, this association was modified by serum cholesterol status. Location and UV index were the strongest factors associated with 25(OH)D < 75 nmol L-1. Cholesterol, the product of an alternative steroid pathway with a common precursor steroid, modified the effect of antiretroviral therapy on serum 25(OH)D. © 2014 The American Society of Photobiology.

Details

Title: Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus
Authors: K M Klassen (Author) - University of Melbourne
C K Fairley (Author) - Monash University
Michael G Kimlin (Author) - Queensland University of Technology
M Kelly (Author) - Queensland Health
T R H Read (Author) - Monash University
J Broom (Author) - University of Queensland
D B Russell (Author) - University of Melbourne
P R Ebeling (Author) - University of Melbourne
Publication details: Photochemistry and Photobiology, Vol.91(2), pp.431-437
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2015
DOI: 10.1111/php.12390
ISSN: 0031-8655
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449225002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics

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