Type III Secretion à la Chlamydia

Jan M Peters; David P Wilson; Garry Myers; Peter Timms; Patrik M Bavoil

doi:10.1016/j.tim.2007.04.005

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Journal article

Open access

Peer reviewed

Type III Secretion à la Chlamydia

Jan M Peters, David P Wilson, Garry Myers, Peter Timms and Patrik M Bavoil

Trends in Microbiology, Vol.15(6), pp.241-251

2007

DOI: https://doi.org/10.1016/j.tim.2007.04.005

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Abstract

Microbiology

Medical Microbiology

Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial growth and late differentiation, suggest that chlamydiae contained in small non-fusogenic inclusions will persist. Here, we further discuss the model in the context of in vitro-persistent, stress-induced aberrantly enlarged forms and of recent studies using small molecule inhibitors of T3S. A general mechanism is emerging whereby both early- and mid-cycle T3S-mediated activities and late T3S inactivation upon detachment of chlamydiae from the inclusion membrane are crucial for chlamydial intracellular development.

Details

Title: Type III Secretion à la Chlamydia
Authors: Jan M Peters (Author) - University of Maryland, United States
David P Wilson (Author) - University of New South Wales
Garry Myers (Author) - Institute for Genomic Research, United States
Peter Timms (Author) - Queensland University of Technology
Patrik M Bavoil (Author) - University of Maryland, United States
Publication details: Trends in Microbiology, Vol.15(6), pp.241-251
Publisher: Elsevier Ltd.
Date published: 2007
DOI: 10.1016/j.tim.2007.04.005
ISSN: 0966-842X; 0966-842X
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449332902621
Output Type: Journal article
Research Statement: false

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Microbiology

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