Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

K E Froud; A C Y Wong; J M E Cederholm; M Klugmann; Shaun L Sandow; J P Julien; A F Ryan; G D Housley

doi:10.1038/ncomms8115

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Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

Journal article

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Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

K E Froud, A C Y Wong, J M E Cederholm, M Klugmann, Shaun L Sandow, J P Julien, A F Ryan and G D Housley

Nature Communications, Vol.6(7115)

2015

DOI: https://doi.org/10.1038/ncomms8115

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Abstract

neuroscience

biological sciences

The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear. Such efferent feedback is important for promoting discrimination of sounds in background noise, sound localization and protecting the cochleae from acoustic overstimulation. However, the sensory driver for the olivocochlear reflex is unknown. Here, we resolve this longstanding question using a mouse model null for the gene encoding the type III intermediate filament peripherin (Prph). Prph(−/−) mice lacked type II spiral ganglion neuron innervation of the outer hair cells, whereas innervation of the inner hair cells by type I spiral ganglion neurons was normal. Compared with Prph(+/+) controls, both contralateral and ipsilateral olivocochlear efferent-mediated suppression of the cochlear amplifier were absent in Prph(−/−) mice, demonstrating that outer hair cells and their type II afferents constitute the sensory drive for the olivocochlear efferent reflex.

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Title: Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
Authors: K E Froud (Author) - University of New South Wales
A C Y Wong (Author) - University of New South Wales
J M E Cederholm (Author) - University of New South Wales
M Klugmann (Author) - University of New South Wales
Shaun L Sandow (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
J P Julien (Author) - Laval University, Canada
A F Ryan (Author) - University of California San Diego, United States
G D Housley (Author) - University of New South Wales
Publication details: Nature Communications, Vol.6(7115); 9
Publisher: Nature Publishing Group
Date published: 2015
DOI: 10.1038/ncomms8115
ISSN: 2041-1723
Copyright note: Copyright © 2015 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449386702621
Output Type: Journal article

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Web Of Science research areas: Neurosciences

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