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Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection1.95 MB
Published VersionCC BY V4.0, Open Access
Journal article
Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection
Frontiers in Cellular and Infection Microbiology, Vol.11, pp.714440-714440
2021
PMID: 34595130
Abstract
People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.
Details
- Title
- Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection
- Authors
- Jane E. Sinclair (Author) - The University of QueenslandConor J. Bloxham (Author) - The University of QueenslandHan Chiu (Author) - The University of QueenslandKeng Yih Chew (Author) - The University of QueenslandJake Russell (Author) - Univ Queensland, Sch Biomed Sci, Brisbane, Qld, AustraliaYusuke Yoshikawa (Author) - The University of QueenslandHelle Bielefeldt-Ohmann (Author) - The University of QueenslandLauren E. Steele (Author) - The University of QueenslandKatina D. Hulme (Author) - The University of QueenslandNathalie Aj Verzele (Author) - The University of QueenslandEllesandra C. Noye (Author) - The University of QueenslandMelanie Wu (Author) - Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, AustraliaMelissa E. Reichelt (Author) - The University of QueenslandWalter G. Thomas (Author) - The University of QueenslandLinda A. Gallo (Author) - The University of QueenslandMeredith A. Redd (Author) - The University of QueenslandKirsty R. Short (Corresponding Author) - The University of Queensland
- Publication details
- Frontiers in Cellular and Infection Microbiology, Vol.11, pp.714440-714440; 7
- Publisher
- Frontiers Research Foundation
- Date published
- 2021
- DOI
- 10.3389/fcimb.2021.714440
- ISSN
- 2235-2988
- PMID
- 34595130
- Copyright note
- Copyright © 2021 Sinclair, Bloxham, Chiu, Chew, Russell, Yoshikawa, Bielefeldt-Ohmann, Steele, Hulme, Verzele, Noye, Wu, Reichelt, Thomas, Gallo, Redd and Short. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99679195002621
- Output Type
- Journal article
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- Immunology
- Microbiology
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