Journal article
Treatment response with ketamine in chronic suicidality: An open label functional connectivity study
Journal of Affective Disorders, Vol.331, pp.92-100
2023
PMID: 36963514
Appears in Thompson Institute Research Collection
Abstract
Background: Ketamine has recently been proposed as a treatment option for suicidality. Whilst its mechanism of action has been explored at molecular levels, the effect on the brain at the organ level remains unclear. Here we investigate immediate post treatment and prolonged large scale resting state neural network changes to elucidate the neuronal underpinnings associated with ketamine's therapeutic effects.
Methods: Twenty eight adults (aged 22–72 years) participated in the Oral Ketamine Trial On Suicidality, which is an open label trial of weekly sub anaesthetic doses of oral ketamine over 6 weeks. MRI was acquired at baseline, post treatment, and follow up. Functional connectivity changes at post treatment and follow up were examined using seed based and independent component analysis. Results: The seed based connectivity analysis revealed significantly reduced connectivity at post treatment from the right hippocampus to both right and left superior frontal gyrus, from the left anterior parahippocampus to right superior frontal gyrus, left superior frontal gyrus, right middle frontal gyrus, and left frontal operculum cortex. Compared with baseline, the ICA showed reduced anterior default mode network connectivities to bilateral posterior cingulate cortex, middle and anterior cingulate cortex, lingual gyrus, and cuneus and increased connectivity of the frontoparietal network to the right superior parietal lobule at post treatment.
Details
- Title
- Treatment response with ketamine in chronic suicidality: An open label functional connectivity study
- Authors
- Adem T Can (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAbdalla Z Mohamed (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteZack Y Shan (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMegan Dutton (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteCyrana Gallay (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteGrace Forsyth (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel Jamieson (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Journal of Affective Disorders, Vol.331, pp.92-100
- Publisher
- Elsevier BV
- Date published
- 2023
- DOI
- 10.1016/j.jad.2023.03.064
- ISSN
- 1573-2517
- PMID
- 36963514
- Grant note
- 2017–2018 Federal Budget/ Prioritising Mental Health Research initiative
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99714998502621
- Output Type
- Journal article
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- Clinical Neurology
- Psychiatry
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