Treatment of rectal chlamydia infection may be more complicated than we originally thought

Jane S Hocking; Fabian Y S Kong; Peter Timms; Wilhelmina M Huston; Sepehr N Tabrizi

doi:10.1093/jac/dku493

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Treatment of rectal chlamydia infection may be more complicated than we originally thought

Journal article

Peer reviewed

Treatment of rectal chlamydia infection may be more complicated than we originally thought

Jane S Hocking, Fabian Y S Kong, Peter Timms, Wilhelmina M Huston and Sepehr N Tabrizi

Journal of Antimicrobial Chemotherapy, Vol.70(4), pp.961-964

2014

DOI: https://doi.org/10.1093/jac/dku493

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Abstract

azithromycin

doxycycline

treatment failure

Rectal chlamydia diagnoses have been increasing among MSM and may also rise among women as anal sex rates increase among heterosexuals. However, there is growing concern about treatment for rectal chlamydia with treatment failures of up to 22% being reported. This article addresses factors that may be contributing to treatment failure for rectal chlamydia, including the pharmacokinetic properties of azithromycin and doxycycline in rectal tissue, the ability of chlamydia to transform into a persistent state that is less responsive to antimicrobial therapy, the impact of the rectal microbiome on chlamydia, heterotypic resistance, failure to detect cases of lymphogranuloma venereum and the performance of screening tests. If we are to reduce the burden of genital chlamydia, treatment for rectal chlamydia must be efficacious. This highlights the need for randomized controlled trial evidence comparing azithromycin with doxycycline for the treatment of rectal chlamydia.

Details

Title: Treatment of rectal chlamydia infection may be more complicated than we originally thought
Authors: Jane S Hocking (Author) - University of Melbourne
Fabian Y S Kong (Author) - University of Melbourne
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Wilhelmina M Huston (Author) - Queensland University of Technology
Sepehr N Tabrizi (Author) - University of Melbourne
Publication details: Journal of Antimicrobial Chemotherapy, Vol.70(4), pp.961-964
Publisher: Oxford University Press
Date published: 2014
DOI: 10.1093/jac/dku493
ISSN: 0305-7453
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449817802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Infectious Diseases; Microbiology; Pharmacology & Pharmacy

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