Treatment of Chlamydia-associated ocular disease via a recombinant protein based vaccine in the koala (Phascolarctos cinereus)

Courtney Waugh; Ray Austin; Adam Polkinghorne; Peter Timms

doi:10.1016/j.biologicals.2016.09.006

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Treatment of Chlamydia-associated ocular disease via a recombinant protein based vaccine in the koala (Phascolarctos cinereus)

Journal article

Peer reviewed

Treatment of Chlamydia-associated ocular disease via a recombinant protein based vaccine in the koala (Phascolarctos cinereus)

Courtney Waugh, Ray Austin, Adam Polkinghorne and Peter Timms

Biologicals, Vol.44(6), pp.588-590

2016

DOI: https://doi.org/10.1016/j.biologicals.2016.09.006

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Abstract

vaccine

koala

chlamydia pecorum

therapeutic vaccine

major outer membrane protein

Koalas (Phascolarctos cinereus) are affected by debilitating chlamydial disease that can lead to blindness, infertility, and death. The causative agent is the intracellular bacterium Chlamydia pecorum. While antibiotics can be used to treat koala chlamydial infection, they are often ineffective or cause severe dysbiosis to the animal's unique gut flora. Recent work has progressed on the development of a protective vaccine for Chlamydia in the koala. This study demonstrates that the use of a vaccine can have a positive effect in koalas already with clinical signs of ocular disease, suggesting a possible therapeutic effect and an alternative to antibiotic therapy.

Details

Title: Treatment of Chlamydia-associated ocular disease via a recombinant protein based vaccine in the koala (Phascolarctos cinereus)
Authors: Courtney Waugh (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Ray Austin (Author) - Keen Street Veterinary Clinic, Lismore
Adam Polkinghorne (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Biologicals, Vol.44(6), pp.588-590
Publisher: Academic Press
Date published: 2016
DOI: 10.1016/j.biologicals.2016.09.006
ISSN: 1045-1056
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451170302621
Output Type: Journal article

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