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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Transient Cerebral Blood Flow Responses During Microgravity
Life Sciences in Space Research, Vol.25, pp.66-71
2020
Abstract
Purpose: A number of studies has well described central cardiovascular changes caused by changing gravity levels as they occur e.g. during parabolic flight. limited data exists describing the effect of microgravity on the cerebrovascular system and brain perfusion. Methods: In this study middle cerebral artery velocity (MCAv) of 16 participants was continuously monitored on a second-by-second basis during 15 consecutive parabolas (1G, 1,8G, 0G, 1,8G) using doppler ultrasound. Simultaneously central cardiovascular parameters (heart rate, mean arterial blood pressure, cardiac output) were assessed. Results: Results revealed an immediate reaction of central cardiovascular parameters to changed gravity levels. In contrast, changes in MCAv only initially were in accordance with a normal cerebral autoregulation. Whereas all of the measured central cardiovascular parameters seemed to have reached a steady state after approximately 8 seconds of microgravity, MCAv, after an initial decrease with the onset of microgravity, increased again during the second half of the microgravity phase. Conclusion: It is concluded that this increase in MCAv during the second half of the microgravity period reflects a decrease of cerebrovascular resistance caused by a pressure driven increased venous outflow and/or a contraction of precapillary sphincters in order to avoid hyperperfusion of the brain.
Details
- Title
- Transient Cerebral Blood Flow Responses During Microgravity
- Authors
- Timo Klein (Author) - University of the Sunshine CoastMarit Sanders (Author) - Radboud University Medical Centre, NetherlandsPetra Wollseiffen (Author) - German Sport University Cologne, GermanyHeather Carnahan (Author) - Memorial University of Newfoundland, CanadaVera Abeln (Author)Christopher D Askew (Author) - University of the Sunshine CoastJurgen Claassen (Author) - Radboud University Medical Centre, NetherlandsStefan Schneider (Author) - University of the Sunshine Coast
- Publication details
- Life Sciences in Space Research, Vol.25, pp.66-71
- Publisher
- Elsevier BV
- Date published
- 2020
- DOI
- 10.1016/j.lssr.2020.03.003
- ISSN
- 2214-5524
- Copyright note
- Copyright © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450972002621
- Output Type
- Journal article
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