Transient Cerebral Blood Flow Responses During Microgravity

Timo Klein; Marit Sanders; Petra Wollseiffen; Heather Carnahan; Vera Abeln; Christopher D Askew; Jurgen Claassen; Stefan Schneider

doi:10.1016/j.lssr.2020.03.003

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Transient Cerebral Blood Flow Responses During Microgravity

Journal article

Open access

Peer reviewed

Transient Cerebral Blood Flow Responses During Microgravity

Timo Klein, Marit Sanders, Petra Wollseiffen, Heather Carnahan, Vera Abeln, Christopher D Askew, Jurgen Claassen and Stefan Schneider

Life Sciences in Space Research, Vol.25, pp.66-71

2020

DOI: https://doi.org/10.1016/j.lssr.2020.03.003

PMID: 32414494

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Abstract

weightlessness

cerebral blood flow

middle cerebral artery

hypergravity

Purpose: A number of studies has well described central cardiovascular changes caused by changing gravity levels as they occur e.g. during parabolic flight. limited data exists describing the effect of microgravity on the cerebrovascular system and brain perfusion. Methods: In this study middle cerebral artery velocity (MCAv) of 16 participants was continuously monitored on a second-by-second basis during 15 consecutive parabolas (1G, 1,8G, 0G, 1,8G) using doppler ultrasound. Simultaneously central cardiovascular parameters (heart rate, mean arterial blood pressure, cardiac output) were assessed. Results: Results revealed an immediate reaction of central cardiovascular parameters to changed gravity levels. In contrast, changes in MCAv only initially were in accordance with a normal cerebral autoregulation. Whereas all of the measured central cardiovascular parameters seemed to have reached a steady state after approximately 8 seconds of microgravity, MCAv, after an initial decrease with the onset of microgravity, increased again during the second half of the microgravity phase. Conclusion: It is concluded that this increase in MCAv during the second half of the microgravity period reflects a decrease of cerebrovascular resistance caused by a pressure driven increased venous outflow and/or a contraction of precapillary sphincters in order to avoid hyperperfusion of the brain.

Details

Title: Transient Cerebral Blood Flow Responses During Microgravity
Authors: Timo Klein (Author) - University of the Sunshine Coast
Marit Sanders (Author) - Radboud University Medical Centre, Netherlands
Petra Wollseiffen (Author) - German Sport University Cologne, Germany
Heather Carnahan (Author) - Memorial University of Newfoundland, Canada
Vera Abeln (Author)
Christopher D Askew (Author) - University of the Sunshine Coast
Jurgen Claassen (Author) - Radboud University Medical Centre, Netherlands
Stefan Schneider (Author) - University of the Sunshine Coast
Publication details: Life Sciences in Space Research, Vol.25, pp.66-71
Publisher: Elsevier BV
Date published: 2020
DOI: 10.1016/j.lssr.2020.03.003
ISSN: 2214-5524
PMID: 32414494
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450972002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Astronomy & Astrophysics; Biology

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