Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

Jordanna S. Master; Monika A. Zimanyi; Kom V. Yin; Karen M. Moritz; Linda A. Gallo; Melanie Tran; Mary E. Wlodek; Mary J. Black

doi:10.1111/1440-1681.12303

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Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

Journal article

Peer reviewed

Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

Jordanna S. Master, Monika A. Zimanyi, Kom V. Yin, Karen M. Moritz, Linda A. Gallo, Melanie Tran, Mary E. Wlodek and Mary J. Black

Clinical and Experimental Pharmacology & Physiology, Vol.41(11), pp.884-890

2014

DOI: https://doi.org/10.1111/1440-1681.12303

PMID: 25199478

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Abstract

blood pressure

cardiomyocyte number

growth restriction

left ventricular hypertrophy

transgenerational transmission

Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subsequent generations. The aim of the present study was to examine the effect of intrauterine growth restriction in rats, induced by uteroplacental insufficiency, on cardiac structure, number, size, nuclearity, and adult blood pressure in first (F1) and second (F2) generation male offspring. Uteroplacental insufficiency or sham surgery was induced in F0 Wistar-Kyoto pregnant rats in late gestation giving rise to F1 restricted and control offspring, respectively. F1 control and restricted females were mated with normal males, resulting in F2 control and restricted offspring, respectively. F1 restricted male offspring were significantly lighter at birth (P<0.05), but there were no differences in birthweight of F2 offspring. Left ventricular weights and volumes were significantly increased (P<0.05) in F1 and F2 restricted offspring at day35. Left ventricular cardiomyocyte number was not different in F1 and F2 restricted offspring. At 6months-of-age, F1 and F2 restricted offspring had elevated blood pressure (8-15mmHg, P<0.05). Our findings demonstrate the emergence of left ventricular hypertrophy and hypertension, with no change in cardiomyocyte number, in F1 restricted male offspring, and this was transmitted to the F2 offspring. The findings support transgenerational programming effects.

Details

Title: Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats
Authors: Jordanna S. Master (Author) - University of Melbourne
Monika A. Zimanyi (Author) - Monash University
Kom V. Yin (Author) - Monash University
Karen M. Moritz (Author) - University of Queensland
Linda A. Gallo (Author) - University of Melbourne
Melanie Tran (Author) - University of Melbourne
Mary E. Wlodek (Corresponding Author) - University of Melbourne
Mary J. Black (Author) - Monash University
Publication details: Clinical and Experimental Pharmacology & Physiology, Vol.41(11), pp.884-890
Publisher: John Wiley & Sons, Inc.
DOI: 10.1111/1440-1681.12303
ISSN: 1440-1681
PMID: 25199478
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
Language: English
Record Identifier: 99679194402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Pharmacology & Pharmacy; Physiology

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