Journal article
Transfusion-related acute lung injury (TRALI): Potential pathways of development, strategies for prevention and treatment, and future research directions
Blood Reviews, Vol.53, pp.1-30
2022
PMID: 35065815
Abstract
Transfusion-related acute lung injury (TRALI) can occur during or after a transfusion, and remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused by the transfusion of either anti-leukocyte antibodies or biological response modifiers (BRMs). Experimental evidence suggests at least six different pathways that antibody-mediated TRALI might follow: (i) two hit neutrophil activation; (ii) monocyte and neutrophil dependent; (iii) endothelial cell, neutrophil Fc receptor, platelet and neutrophil extracellular trap dependent; (iv) direct monocyte activation; (v) direct endothelial cell activation; and (vi) endothelial cell, complement and monocyte dependent. Two of these pathways (i and v) also apply to BRM-mediated TRALI. Different antibodies or BRMs might initiate different pathways. Even though six pathways are described, these might not be distinct, and might instead be interlinked or proceed concurrently. The different pathways converge upon reactive oxygen species release which damages pulmonary endothelium, precipitating fluid leakage and the clinical symptoms of TRALI. This review also discusses evidence of protective mechanisms and their implications for clinical TRALI treatment. Finally, it suggests directions for future research to support the translation of these findings into strategies to prevent and treat clinical TRALI.
Details
- Title
- Transfusion-related acute lung injury (TRALI): Potential pathways of development, strategies for prevention and treatment, and future research directions
- Authors
- John-Paul Tung (Author) - Australian Red Cross LifebloodSara Chiaretti (Author) - Australian Red Cross LifebloodMelinda M Dean (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyAnnette J Sultana (Author) - The University of QueenslandMichael C Reade (Author) - The University of QueenslandYoke Lin Fung (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Blood Reviews, Vol.53, pp.1-30
- Publisher
- Elsevier Ltd.
- Date published
- 2022
- DOI
- 10.1016/j.blre.2021.100926
- ISSN
- 1532-1681
- PMID
- 35065815
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99595308602621
- Output Type
- Journal article
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- Domestic collaboration
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- Hematology
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