Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions

C C Silliman; Yoke Lin Fung; J Bradley Ball; S Y Khan

doi:10.1016/j.blre.2009.07.005

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Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions

Journal article

Open access

Peer reviewed

Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions

C C Silliman, Yoke Lin Fung, J Bradley Ball and S Y Khan

Blood Reviews, Vol.23(6), pp.245-255

2009

DOI: https://doi.org/10.1016/j.blre.2009.07.005

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Abstract

neutrophils

priming

two event model

antibodies

lipids

Transfusion-related acute lung injury (TRALI) is the most common cause of serious morbidity and mortality due to hemotherapy. Although the pathogenesis has been related to the infusion of donor antibodies into the recipient, antibody negative TRALI has been reported. Changes in transfusion practices, especially the use of male-only plasma, have decreased the number of antibody-mediated cases and deaths; however, TRALI still occurs. The neutrophil appears to be the effector cell in TRALI and the pathophysiology is centered on neutrophil-mediated endothelial cell cytotoxicity resulting in capillary leak and ALI. This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer. © 2009 Elsevier Ltd. All rights reserved.

Details

Title: Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions
Authors: C C Silliman (Author) - University of Colorado, United States
Yoke Lin Fung (Author) - Australian Red Cross Blood Service
J Bradley Ball (Author) - University of Colorado, United States
S Y Khan (Author) - University of Colorado, United States
Publication details: Blood Reviews, Vol.23(6), pp.245-255
Publisher: Churchill Livingstone
Date published: 2009
DOI: 10.1016/j.blre.2009.07.005
ISSN: 0268-960X
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449011202621
Output Type: Journal article

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Web Of Science research areas: Hematology

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