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Published VersionCC BY-NC V4.0, Open Access
Journal article
Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
BMJ Open, Vol.13, pp.1-11
2023
Abstract
Introduction: Regular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the association between greater cardiorespiratory fitness and larger brain volume, superior cognitive performance and lower dementia risk. However, the optimal aerobic exercise dose, namely the intensity and mode of delivery, to improve brain health and lower dementia risk has received less attention. We aim to determine the effect of different doses of aerobic exercise training on markers of brain health in sedentary middle-aged adults, hypothesising that high-intensity interval training (HIIT) will be more beneficial than moderate-intensity continuous training (MICT).
Methods and analysis: In this two-group parallel, open-label blinded endpoint randomised trial, 70 sedentary middle-aged (45–65 years) adults will be randomly allocated to one of two 12-week aerobic exercise training interventions matched for total exercise training volume: (1) MICT (n=35) or HIIT (n=35). Participants will perform ~50 min exercise training sessions, 3 days per week, for 12 weeks. The primary outcome will be measured as between-group difference in cardiorespiratory fitness (peak oxygen uptake) change from baseline to the end of training. Secondary outcomes include between-group differences in cognitive function and ultra-high field MRI (7T) measured markers of brain health (brain blood flow, cerebrovascular function, brain volume, white matter microstructural integrity and resting state functional brain activity) changes from baseline to the end of training.
Ethics and dissemination: The Victoria University Human Research Ethics Committee (VUHREC) has approved this study (HRE20178), and all protocol modifications will be communicated to the relevant parties (eg, VUHREC, trial registry). Findings from this study will be disseminated via peer-review publications, conference presentations, clinical communications and both mainstream and social media.
Trial registration number: ANZCTR12621000144819.
Details
- Title
- Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
- Authors
- James R Broatch (Corresponding Author) - Victoria UniversityNavabeh Zarekookandeh (Author) - Victoria UniversityRebecca Glarin (Author) - The University of MelbourneMyrte Strik (Author) - The University of MelbourneLeigh A Johnston (Author) - The University of MelbourneBrad A Moffat (Author) - The University of MelbourneLaura J Bird (Author) - Monash UniversityKate Gunningham (Author) - Victoria UniversityLeonid Churilov (Author) - The University of MelbourneHannah T Johns (Author) - The University of MelbourneChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise ScienceItamar Levinger (Author) - Victoria UniversityShane F O'Riordan (Author) - Victoria UniversityDavid Bishop (Author) - Victoria UniversityAmy Brodtmann (Author) - The University of Melbourne
- Publication details
- BMJ Open, Vol.13, pp.1-11
- Publisher
- BMJ Group
- Date published
- 2023
- DOI
- 10.1136/bmjopen-2022-069413
- ISSN
- 2044-6055
- Copyright note
- © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
- Organisation Unit
- Cancer Research Cluster; School of Health - Sports & Exercise Science
- Language
- English
- Record Identifier
- 99723198902621
- Output Type
- Journal article
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