Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults

James R Broatch; Navabeh Zarekookandeh; Rebecca Glarin; Myrte Strik; Leigh A Johnston; Brad A Moffat; Laura J Bird; Kate Gunningham; Leonid Churilov; Hannah T Johns; Christopher Askew; Itamar Levinger; Shane F O'Riordan; David Bishop; Amy Brodtmann

doi:10.1136/bmjopen-2022-069413

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Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults

Journal article

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Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults

James R Broatch, Navabeh Zarekookandeh, Rebecca Glarin, Myrte Strik, Leigh A Johnston, Brad A Moffat, Laura J Bird, Kate Gunningham, Leonid Churilov, Hannah T Johns, …

BMJ Open, Vol.13, pp.1-11

2023

DOI: https://doi.org/10.1136/bmjopen-2022-069413

PMCID: PMC10230901

PMID: 37225276

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Abstract

Introduction: Regular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the association between greater cardiorespiratory fitness and larger brain volume, superior cognitive performance and lower dementia risk. However, the optimal aerobic exercise dose, namely the intensity and mode of delivery, to improve brain health and lower dementia risk has received less attention. We aim to determine the effect of different doses of aerobic exercise training on markers of brain health in sedentary middle-aged adults, hypothesising that high-intensity interval training (HIIT) will be more beneficial than moderate-intensity continuous training (MICT). Methods and analysis: In this two-group parallel, open-label blinded endpoint randomised trial, 70 sedentary middle-aged (45–65 years) adults will be randomly allocated to one of two 12-week aerobic exercise training interventions matched for total exercise training volume: (1) MICT (n=35) or HIIT (n=35). Participants will perform ~50 min exercise training sessions, 3 days per week, for 12 weeks. The primary outcome will be measured as between-group difference in cardiorespiratory fitness (peak oxygen uptake) change from baseline to the end of training. Secondary outcomes include between-group differences in cognitive function and ultra-high field MRI (7T) measured markers of brain health (brain blood flow, cerebrovascular function, brain volume, white matter microstructural integrity and resting state functional brain activity) changes from baseline to the end of training. Ethics and dissemination: The Victoria University Human Research Ethics Committee (VUHREC) has approved this study (HRE20178), and all protocol modifications will be communicated to the relevant parties (eg, VUHREC, trial registry). Findings from this study will be disseminated via peer-review publications, conference presentations, clinical communications and both mainstream and social media. Trial registration number: ANZCTR12621000144819.

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Title: Train Smart Study: Protocol for a randomized trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
Authors: James R Broatch (Corresponding Author) - Victoria University
Navabeh Zarekookandeh (Author) - Victoria University
Rebecca Glarin (Author) - The University of Melbourne
Myrte Strik (Author) - The University of Melbourne
Leigh A Johnston (Author) - The University of Melbourne
Brad A Moffat (Author) - The University of Melbourne
Laura J Bird (Author) - Monash University
Kate Gunningham (Author) - Victoria University
Leonid Churilov (Author) - The University of Melbourne
Hannah T Johns (Author) - The University of Melbourne
Christopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise Science
Itamar Levinger (Author) - Victoria University
Shane F O'Riordan (Author) - Victoria University
David Bishop (Author) - Victoria University
Amy Brodtmann (Author) - The University of Melbourne
Publication details: BMJ Open, Vol.13, pp.1-11
Publisher: BMJ Group
Date published: 2023
DOI: 10.1136/bmjopen-2022-069413
ISSN: 2044-6055
PMID: 37225276; PMC10230901
Copyright note: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Organisation Unit: Cancer Research Cluster; School of Health - Sports & Exercise Science
Language: English
Record Identifier: 99723198902621
Output Type: Journal article

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Web Of Science research areas: Neurosciences

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