Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves

S Dewanjee; R Sahu; S Karmakar; Moumita Gangopadhyay

doi:10.1016/j.fct.2012.12.040

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Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves

Journal article

Peer reviewed

Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves

S Dewanjee, R Sahu, S Karmakar and Moumita Gangopadhyay

Food and Chemical Toxicology, Vol.55, pp.78-91

2013

DOI: https://doi.org/10.1016/j.fct.2012.12.040

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Abstract

antioxidant

corchorus olitorius

lead toxicity

oxidative stress

pb-acetate

Lead (Pb) is considered to be a multi-target toxicant. The present study was undertaken to evaluate the protective effect of aqueous extract of Corchorus olitorius leaves against Pb-acetate induced toxic manifestation in blood, liver, kidney, brain and heart of Wistar rats. The Pb-acetate (5 mg/kg body weight) treated rats exhibited a significant inhibition of co-enzymes Q, antioxidant enzymes and reduced glutathione levels in the tissues. In addition, the extent of lipid peroxidation, DNA fragmentation and haematological parameters were significantly altered in the Pb-acetate treated rats as compared to control. Simultaneous administration of test extract (25, 50 and 100 mg/kg body weight), could significantly restore the biochemical and haematological parameters near to the normal status through antioxidant activity and/or by preventing bioaccumulation of Pb within the tissues of experimental rats. Presence of substantial quantity of phenolics and flavonoids in the extract may be responsible for the observed protective role against Pb-intoxication.

Details

Title: Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves
Authors: S Dewanjee (Author) - Jadavpur University, India
R Sahu (Author) - Jadavpur University, India
S Karmakar (Author) - Jadavpur University, India
Moumita Gangopadhyay (Author) - Jadavpur University, India
Publication details: Food and Chemical Toxicology, Vol.55, pp.78-91
Publisher: Pergamon
Date published: 2013
DOI: 10.1016/j.fct.2012.12.040
ISSN: 0278-6915
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450391402621
Output Type: Journal article

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