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Toward objective markers of concussion in sport: A review of white matter and neurometabolic changes in the brain after sports-related concussion
Journal article   Peer reviewed

Toward objective markers of concussion in sport: A review of white matter and neurometabolic changes in the brain after sports-related concussion

S Dimou and Jim Lagopoulos
Journal of Neurotrauma, Vol.31(5), pp.413-424
2014
url
https://doi.org/10.1089/neu.2013.3050View
Published Version

Abstract

Sports-related concussion is an issue that has piqued the public's attention of late as concerns surrounding potential long-term sequelae as well as new methods of characterizing the effects of this form of injury continue to develop. For the most part, diagnosis of concussion is based on subjective clinical measures and thus is prone to under-reporting. In the current environment, where conventional imaging modalities, such as computed tomography and magnetic resonance imaging, are unable to elucidate the degree of white matter damage and neurometabolic change, a discussion of two advanced imaging techniques - diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) - is undertaken with a view to highlighting their potential utility. Our aim is to outline a variety of the approaches to concussion research that have been employed, with special attention given to the clinical considerations and acute complications attributed to concussive injury. DTI and MRS have been at the forefront of research as a result of their noninvasiveness and ease of acquisition, and hence it is thought that the use of these neuroimaging modalities has the potential to aid clinical decision making and management, including guiding return-to-play protocols. © Mary Ann Liebert, Inc.

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Clinical Neurology
Critical Care Medicine
Neurosciences

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