Topical application of temperature-sensitive caerin 1.1 and 1.9 gel inhibits TC-1 tumor growth in mice

Bowei Ma; Jianwei Yuan; Shu Chen; Kunsong Huang; Qianbo Wang; Jianchun Ma; Ruoting Lin; Lu Zhang; Yingying Zhou; Tianfang Wang; Shelley F Walton; Xuan Pan; Guoqiang Chen; Yuejian Wang; Guoying Ni; Xiao Song Liu

Topical application of temperature-sensitive caerin 1.1 and 1.9 gel inhibits TC-1 tumor growth in mice

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Topical application of temperature-sensitive caerin 1.1 and 1.9 gel inhibits TC-1 tumor growth in mice

Bowei Ma, Jianwei Yuan, Shu Chen, Kunsong Huang, Qianbo Wang, Jianchun Ma, Ruoting Lin, Lu Zhang, Yingying Zhou, Tianfang Wang, …

American Journal of Translational Research, Vol.12(1), pp.191-202

2020

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Abstract

Clinical Sciences

caerin peptides

genital warts

gel

Genital warts, which are one of the most common sexually transmitted diseases (STDs), result from persistent infection with human papillomavirus (HPV), especially subtypes 6 or 11. Topical application of 5% imiquimod cream is currently recommended as a first-line treatment choice for genital warts, but the clearance and patient compliance rates remain less than sufficient. In the current study, we developed a temperature-sensitive gel that contains the host-defense peptides caerin 1.1 and 1.9, which were originally isolated from Australian tree frogs of the genus Litoria. Growth of HPV16 E6/E7-transformed TC-1 cells was inhibited in vitro and in vivo following injection of the tumor with the caerin gel in a TC-1 tumor mouse model. Furthermore, when the caerin gel was topically applied, the inhibitory effect remained, and T, NK cells were attracted to the tumor site. In addition, the gel maintained a similar level of bioactivity after incubation at room temperature for 30 days. Our results suggest that this caerin gel, following further optimization, may provide an alternative method for the management of genital warts.

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Title: Topical application of temperature-sensitive caerin 1.1 and 1.9 gel inhibits TC-1 tumor growth in mice
Authors: Bowei Ma (Author) - Guangdong Pharmaceutical University, China
Jianwei Yuan (Author) - Guangdong Pharmaceutical University, China
Shu Chen (Author) - Foshan First People's Hospital, China
Kunsong Huang (Author) - Guangdong Pharmaceutical University, China
Qianbo Wang (Author) - Guangdong Pharmaceutical University, China
Jianchun Ma (Author) - Guangdong Pharmaceutical University, China
Ruoting Lin (Author) - Guangdong Pharmaceutical University, China
Lu Zhang (Author) - Guangdong Pharmaceutical University, China
Yingying Zhou (Author) - Guangdong Pharmaceutical University, China
Tianfang Wang (Author) - University of the Sunshine Coast
Shelley F Walton (Author) - University of the Sunshine Coast
Xuan Pan (Author) - Guangdong Pharmaceutical University, China
Guoqiang Chen (Author) - Foshan First People's Hospital, China
Yuejian Wang (Author) - Foshan First People's Hospital, China
Guoying Ni (Author) - University of the Sunshine Coast
Xiao Song Liu (Author) - University of the Sunshine Coast
Publication details: American Journal of Translational Research, Vol.12(1), pp.191-202
Publisher: E-Century Publishing Corporation
Date published: 2020
ISSN: 1943-8141
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450831602621
Output Type: Journal article

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