Journal article
Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
Frontiers in Molecular Neuroscience, Vol.10, 442
2018
PMCID: PMC5767327
PMID: 29375305
Abstract
Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico-striato-thalamic loop, responsible for the initiation of voluntary movements and motor learning. GABAergic transmission exerts the main inhibitory control of MSNs. However, MSNs also express chloride-permeable glycine receptors (GlyRs) although their subunit composition and functional significance in the striatum is unknown. Here, we studied the function of GlyRs in MSNs of young adult mice. We show that MSNs express functional GlyRs, with α2 being the main agonist binding subunit. These receptors are extrasynaptic and depolarizing at resting state. The pharmacological inhibition of GlyRs, as well as inactivation of the GlyR α2 subunit gene hyperpolarize the membrane potential of MSNs and increase their action potential firing offset. Mice lacking GlyR α2 showed impaired motor memory consolidation without any changes in the initial motor performance. Taken together, these results demonstrate that tonically active GlyRs regulate the firing properties of MSNs and may thus affect the function of basal ganglia.
Details
- Title
- Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
- Authors
- Svetlana M Molchanova (Author) - Universite Libre de Bruxelles, BelgiumJoris Comhair (Author) - Universite Libre de Bruxelles, BelgiumDeniz Karadurmus (Author) - Universite Libre de Bruxelles, BelgiumElisabeth Piccart (Author) - University of Hasselt, BelgiumRobert J Harvey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJean-Michel Rigo (Author) - University of Hasselt, BelgiumSerge N Schiffmann (Author) - Universite Libre de Bruxelles, BelgiumBert Brone (Author) - University of Hasselt, BelgiumDavid Gall (Author) - Universite Libre de Bruxelles, Belgium
- Publication details
- Frontiers in Molecular Neuroscience, Vol.10, 442; 12
- Publisher
- Frontiers Research Foundation
- Date published
- 2018
- DOI
- 10.3389/fnmol.2017.00442
- ISSN
- 1662-5099
- PMID
- 29375305; PMC5767327
- Copyright note
- Copyright © 2018 Molchanova, Comhair, Karadurmus, Piccart, Harvey, Rigo, Schiffmann, Brône and Gall. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450331002621
- Output Type
- Journal article
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