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Published VersionCC BY V4.0, Open Access
Journal article
Tissue thickness calculation in ocular optical coherence tomography
Biomedical Optics Express, Vol.7(2), pp.629-645
2016
PMCID: PMC4771476
PMID: 26977367
Abstract
Thickness measurements derived from optical coherence tomography (OCT) images of the eye are a fundamental clinical and research metric, since they provide valuable information regarding the eye's anatomical and physiological characteristics, and can assist in the diagnosis and monitoring of numerous ocular conditions. Despite the importance of these measurements, limited attention has been given to the methods used to estimate thickness in OCT images of the eye. Most current studies employing OCT use an axial thickness metric, but there is evidence that axial thickness measures may be biased by tilt and curvature of the image. In this paper, standard axial thickness calculations are compared with a variety of alternative metrics for estimating tissue thickness. These methods were tested on a data set of wide-field chorio-retinal OCT scans (field of view (FOV) 60 degrees x 25 degrees) to examine their performance across a wide region of interest and to demonstrate the potential effect of curvature of the posterior segment of the eye on the thickness estimates. Similarly, the effect of image tilt was systematically examined with the same range of proposed metrics. The results demonstrate that image tilt and curvature of the posterior segment can affect axial tissue thickness calculations, while alternative metrics, which are not biased by these effects, should be considered. This study demonstrates the need to consider alternative methods to calculate tissue thickness in order to avoid measurement error due to image tilt and curvature.
Details
- Title
- Tissue thickness calculation in ocular optical coherence tomography
- Authors
- David Alonso-Caneiro (Corresponding Author) - Queensland University of TechnologyScott A. Read (Author) - Queensland University of TechnologyStephen J. Vincent (Author) - Queensland University of TechnologyMichael J. Collins (Author) - Queensland University of TechnologyMaciej Wojtkowski (Author) - Nicolaus Copernicus University
- Publication details
- Biomedical Optics Express, Vol.7(2), pp.629-645
- Publisher
- Optica
- Date published
- 2016
- DOI
- 10.1364/BOE.7.000629
- ISSN
- 2156-7085
- PMID
- 26977367; PMC4771476
- Copyright note
- © 2016 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973596602621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging
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