Time dependency of molecular evolutionary rates? Yes and no

Sankar Subramanian; D M Lambert

doi:10.1093/gbe/evr108

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Time dependency of molecular evolutionary rates? Yes and no

Journal article

Open access

Peer reviewed

Time dependency of molecular evolutionary rates? Yes and no

Sankar Subramanian and D M Lambert

Genome Biology and Evolution, Vol.3(1), pp.1324-1328

2011

DOI: https://doi.org/10.1093/gbe/evr108

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Abstract

rates of evolution

natural selection

neutral evolution

time dependency

divergence times

population coalescent times

Some previous studies have suggested that rates of evolution inferred using molecular sequences vary substantially depending on the time frame over which they are measured, whereas a number of other studies have argued against this proposition. We examined this issue by separating positions of primate mitochondrial genomes that are under different levels of selection constraints. Our results revealed an order of magnitude variation in the evolutionary rates at constrained sites (including nonsynonymous sites, D-loop, and RNA) and virtually an identical rate of evolution at synonymous sites, independent of the timescales over which they were estimated. Although the evolutionary rate at nonsynonymous sites obtained using the European (H1 haplogroup) mitogenomes is 9-15 times higher than that estimated using the human- chimpanzee pair, in contrast, the rates at synonymous sites are similar between these comparisons. We also show that the ratio of divergence at nonsynonymous to synonymous sites estimated using intra- and interspecific comparisons vary up to nine times, which corroborates our results independent of calibration times. © The Author(s) 2010.

Details

Title: Time dependency of molecular evolutionary rates? Yes and no
Authors: Sankar Subramanian (Author) - Griffith University
D M Lambert (Author) - Griffith University
Publication details: Genome Biology and Evolution, Vol.3(1), pp.1324-1328
Publisher: Oxford University Press
Date published: 2011
DOI: 10.1093/gbe/evr108
ISSN: 1759-6653
Copyright note: Copyright © The Author(s) 2011. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/ 3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450457302621
Output Type: Journal article

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