Thou shalt not pass - arachnid venom peptides interacting with biological membranes

Yachen Wang; Shaodong Guo; Katie F. Jee; Volker Herzig

doi:10.3389/frchs.2024.1490313

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Thou shalt not pass - arachnid venom peptides interacting with biological membranes

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Thou shalt not pass - arachnid venom peptides interacting with biological membranes

Yachen Wang, Shaodong Guo, Katie F. Jee and Volker Herzig

Frontiers in Arachnid Science, Vol.3, pp.1-13

2024

DOI: https://doi.org/10.3389/frchs.2024.1490313

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Abstract

lipid bilayer

cell-penetrating peptides

blood-brain barrier

insect midgut

membrane-penetrating peptides

spider

scorpion

pseudoscorpion

Arachnid venom peptides receive increasing attention from researchers for possible applications as human therapeutics, as bioinsecticides in agriculture or for targeting vectors of human disease. One commonly perceived disadvantage of peptides in contrast to small molecule drugs is their inability of crossing biological membranes comprised of lipid bilayers, providing a major obstacle for the delivery of peptide-based drugs and bioinsecticides. However, some arachnid venom peptides were reported to cross biological membranes, including cellular membranes, the vertebrate and insect blood brain barrier (BBB) and the insect midgut epithelium. This review will focus on these membrane-permeating arachnid peptides and discuss the underlying mechanisms. Different physico-chemical properties of membrane-permeating arachnid peptides and their contribution to the ability of crossing biological membranes will also be examined. In addition, several methods that facilitate or enable peptides to cross biological membranes will be discussed, which can be employed on peptides with no inherent membrane-permeating capabilities.

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Title: Thou shalt not pass - arachnid venom peptides interacting with biological membranes
Authors: Yachen Wang - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Shaodong Guo - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Katie F. Jee - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Volker Herzig (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Frontiers in Arachnid Science, Vol.3, pp.1-13
Publisher: Frontiers Research Foundation
Date published: 2024
DOI: 10.3389/frchs.2024.1490313
ISSN: 2813-5083
Copyright note: © 2024 Wang, Guo, Jee and Herzig. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Grants: Be(e) friendly venomous spiders! Novel biopesticides from arachnid venoms, FT190100482, Australian Research Council (Australia, Canberra) - ARC
Organisation Unit: School of Science, Technology and Engineering; Student Services and Engagement; Centre for Bioinnovation
Language: English
Record Identifier: 991081298902621
Output Type: Journal article

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