Thermogelling 3D systems towards stem cell-based tissue regeneration therapies

X Wang; David James Young; Y L Wu; X J Loh

doi:10.3390/molecules23030553

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Thermogelling 3D systems towards stem cell-based tissue regeneration therapies

Journal article

Open access

Peer reviewed

Thermogelling 3D systems towards stem cell-based tissue regeneration therapies

X Wang, David James Young, Y L Wu and X J Loh

Molecules, Vol.23(3), 553

2018

DOI: https://doi.org/10.3390/molecules23030553

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Abstract

3D culture

stem cell

thermogel

tissue engineering

Stem cell culturing and differentiation is a very important research direction for tissue engineering. Thermogels are well suited for encapsulating cells because of their non-biotoxic nature and mild sol-gel transition as temperature increases. In particular, thermogels provide a 3D growth environment for stem cell growth, which is more similar to the extracellular matrix than flat substrates, so thermogels as a medium can overcome many of the cell abnormalities caused by 2D cell growth. In this review, we summarize the applications of thermogels in cell and stem cell culture in recent years. We also elaborate on the methods to induce stem cell differentiation by using thermogel-based 3D scaffolds. In particular, thermogels, encapsulating specific differentiation-inducing factor and having specific structures and moduli, can induce the differentiation into the desired tissue cells. Three dimensional thermogel scaffolds that control the growth and differentiation of cells will undoubtedly have a bright future in regenerative medicine. © 2018 by the authors.

Details

Title: Thermogelling 3D systems towards stem cell-based tissue regeneration therapies
Authors: X Wang (Author) - Xiamen University, China
David James Young (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Y L Wu (Author) - Xiamen University, China
X J Loh (Author) - Institute of Materials Science and Engineering, Singapore
Publication details: Molecules, Vol.23(3), 553; 14
Publisher: MDPI AG
Date published: 2018
DOI: 10.3390/molecules23030553
ISSN: 1420-3049
Copyright note: Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450644802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary