The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women

A C Freitas; Bonnie L Chaban; A Bocking; M Rocco; S Yang; J E Hill; D M Money; Sean Hemmingsen; Gregor Reid; Tim Dumonceaux; Gregor Gloor; Matthew Links; Kieran O'Doherty; Patrick Tang; Julianne van Schalkwyk; Mark Yudin

doi:10.1038/s41598-017-07790-9

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The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women

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The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women

A C Freitas, Bonnie L Chaban, A Bocking, M Rocco, S Yang, J E Hill, D M Money, Sean Hemmingsen, Gregor Reid, Tim Dumonceaux, …

Scientific Reports, Vol.7, 9212

2017

DOI: https://doi.org/10.1038/s41598-017-07790-9

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Abstract

microbiome

personalized medicine

The vaginal microbiome plays an important role in maternal and neonatal health. Imbalances in this microbiota (dysbiosis) during pregnancy are associated with negative reproductive outcomes, such as pregnancy loss and preterm birth, but the underlying mechanisms remain poorly understood. Consequently a comprehensive understanding of the baseline microbiome in healthy pregnancy is needed. We characterized the vaginal microbiomes of healthy pregnant women at 11-16 weeks of gestational age (n= 182) and compared them to those of non-pregnant women (n= 310). Profiles were created by pyrosequencing of the cpn60 universal target region. Microbiome profiles of pregnant women clustered into six Community State Types: I, II, III, IVC, IVD and V. Overall microbiome profiles could not be distinguished based on pregnancy status. However, the vaginal microbiomes of women with healthy ongoing pregnancies had lower richness and diversity, lower prevalence of Mycoplasma and Ureaplasma and higher bacterial load when compared to non-pregnant women. Lactobacillus abundance was also greater in the microbiomes of pregnant women with Lactobacillus-dominated CSTs in comparison with non-pregnant women. This study provides further information regarding characteristics of the vaginal microbiome of low-risk pregnant women, providing a baseline for forthcoming studies investigating the diagnostic potential of the microbiome for prediction of adverse pregnancy outcomes.

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Title: The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women
Authors: A C Freitas (Author) - University of Saskatchewan, Canada
Bonnie L Chaban (Author) - University of Saskatchewan, Canada
A Bocking (Author) - University of Toronto, Canada
M Rocco (Author) - Lunenfeld-Tanenbaum Research Institute, Canada
S Yang (Author) - University of Toronto, Canada
J E Hill (Author) - University of Saskatchewan, Canada
D M Money (Author) - University of British Columbia, Canada
Sean Hemmingsen (Author) - National Research Council, Canada
Gregor Reid (Author) - University of Western Ontario, Canada
Tim Dumonceaux (Author) - Agriculture and Agri-Food Canada, Canada
Gregor Gloor (Author) - Lawson Health Research Institute, Canada
Matthew Links (Author) - University of Saskatchewan, Canada
Kieran O'Doherty (Author) - University of Guelph, Canada
Patrick Tang (Author) - Sidra Medical and Research Center, Qatar
Julianne van Schalkwyk (Author) - University of Saskatchewan, Canada
Mark Yudin (Author) - University of British Columbia, Canada
Publication details: Scientific Reports, Vol.7, 9212; 16
Publisher: John Wiley & Sons Inc.
Date published: 2017
DOI: 10.1038/s41598-017-07790-9
ISSN: 1051-0761
Copyright note: Copyright © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute; Centre for Bioinnovation
Language: English
Record Identifier: 99450466702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology

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