Journal article
The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: A systematic review
BMC Psychiatry, Vol.16, 156
2016
Abstract
Background: Mood and anxiety disorders are leading causes of disability and mortality, due largely to their onset during adolescence and young adulthood and broader impact on functioning. Key factors that are associated with disability and these disorders in young people are social and economic participation (e.g. education, employment), physical health, suicide and self-harm behaviours, and alcohol and substance use. A better understanding of the objective markers (i.e. neurobiological parameters) associated with these factors is important for the development of effective early interventions that reduce the impact of disability and illness persistence. Methods: We systematically reviewed the literature for neurobiological parameters (i.e. neuropsychology, neuroimaging, sleep-wake and circadian biology, neurophysiology and metabolic measures) associated with functional domains in young people (12 to 30 years) with mood and/or anxiety disorders. Results: Of the one hundred and thirty-four studies selected, 7.6% investigated social and economic participation, 2.1% physical health, 15.3% suicide and self-harm behaviours, 6.9% alcohol and substance use, whereas the majority (68.1%) focussed on clinical syndrome. Conclusions: Despite the predominance of studies that solely examine the clinical syndrome of young people the literature also provides evidence of distinct associations among objective measures (indexing various aspects of brain circuitry) and other functional domains. We suggest that a shift in focus towards characterising the mechanisms that underlie and/or mediate multiple functional domains will optimise personalised interventions and improve illness trajectories. © 2016 Iorfino et al.
Details
- Title
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: A systematic review
- Authors
- F Iorfino (Author) - University of SydneyI B Hickie (Author) - University of SydneyR S C Lee (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyDaniel F Hermens (Author) - University of Sydney
- Publication details
- BMC Psychiatry, Vol.16, 156
- Publisher
- BioMed Central Ltd.
- Date published
- 2016
- DOI
- 10.1186/s12888-016-0852-3
- ISSN
- 1471-244X
- Copyright note
- Copyright © 2016 Iorfino et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated..
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450509302621
- Output Type
- Journal article
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- Psychiatry
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