The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils

Yoke Lin Fung; J F Fraser; P Wood; R M Minchinton; C C Silliman

doi:10.1016/j.jcrc.2007.09.004

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The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils

Journal article

Peer reviewed

The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils

Yoke Lin Fung, J F Fraser, P Wood, R M Minchinton and C C Silliman

Journal of Critical Care, Vol.23(4), pp.542-549

2008

DOI: https://doi.org/10.1016/j.jcrc.2007.09.004

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Abstract

systemic inflammatory

response syndrome

hyporesponsiveness

neutrophils

Purpose: To study the effects of systemic inflammatory response syndrome (SIRS) on polymorhonuclear neutrophil (PMN) function and phenotype by comparing neutrophils from critically ill patients with SIRS against those from healthy blood donors. Material and Methods: Intensive care unit patients (n = 110) who met at least one SIRS criterion were recruited to the study. One hundred healthy blood donors were recruited as normal controls. Results: Polymorphonuclear cells from critically ill patients with SIRS were more resistant to activation than PMNs from healthy donors, but when stimulated had an exaggerated microbicidal response. Buffer-treated PMNs from patients with SIRS had significantly higher CD43 surface expression that may inhibit heterotypic cellular contact or ligand stimulation of membrane receptors, had significantly lower expression of IgG receptor CD16, demonstrated resistance to shedding of L-selectin when primed by platelet-activating factor which could be pro-inflammatory, and had reduced respiratory burst when primed by platelet-activating factor than activated by formyl-Met-Leu-Phe. Conclusion: The phenotypic and functional changes observed in neutrophils in the critically ill indicate that they require a higher level of stimulus to become activated. This may represent an auto-protective mechanism where the neutrophils in the already inflamed host may, by this mechanism, avoid excessive inflammation reducing the risk of further host cell injury and death. © 2008 Elsevier Inc. All rights reserved.

Details

Title: The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils
Authors: Yoke Lin Fung (Author) - Australian Red Cross Blood Service
J F Fraser (Author) - Australian Red Cross Blood Service
P Wood (Author) - Australian Red Cross Blood Service
R M Minchinton (Author) - Australian Red Cross Blood Service
C C Silliman (Author) - Australian Red Cross Blood Service
Publication details: Journal of Critical Care, Vol.23(4), pp.542-549
Publisher: W.B. Saunders Co.
Date published: 2008
DOI: 10.1016/j.jcrc.2007.09.004
ISSN: 0883-9441
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448750302621
Output Type: Journal article

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