Journal article
The structure of cardiac glycogen in healthy mice
International Journal of Biological Macromolecules, Vol.51(5), pp.887-891
2012
PMID: 22782068
Abstract
Transmission electron micrographs of glycogen extracted from healthy mouse hearts reveal aggregate structures around 133 nm in diameter. These structures are similar to, but on average somewhat smaller than, the alpha-particles of glycogen found in mammalian liver. Like the larger liver glycogens, these new particles in cardiac tissue appear to be aggregates of beta-particles. Free beta-particles are also present in liver, and are the only type of particle seen in skeletal muscle. They have diameters from 20 to 50 nm. We discuss the number distributions of glycogen particle diameters and the implications for the structure-function relationship of glycogens in these tissues. We point out the possible implications for the study of glycogen storage diseases, and of non-insulin dependent diabetes mellitus.
Details
- Title
- The structure of cardiac glycogen in healthy mice
- Authors
- Quinn A. Besford - University of MelbourneMitchell A Sullivan - University of QueenslandLing Zheng - Wuhan UniversityRobert G. Gilbert - University of QueenslandDavid Stapleton - University of MelbourneAngus A. Gray-Weale (Corresponding Author) - University of Melbourne
- Publication details
- International Journal of Biological Macromolecules, Vol.51(5), pp.887-891
- Publisher
- Elsevier BV
- Date published
- 2012
- DOI
- 10.1016/j.ijbiomac.2012.06.037
- ISSN
- 1879-0003
- PMID
- 22782068
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035098602621
- Output Type
- Journal article
Metrics
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Applied
- Polymer Science
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