The roles of plant dsRNA-binding proteins in RNAi-like pathways

Shaun J. Curtin; John M Watson; Neil A. Smith; Andrew Eamens; Chris L. Blanchard; Peter M. Waterhouse

doi:10.1016/j.febslet.2008.07.004

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The roles of plant dsRNA-binding proteins in RNAi-like pathways

Journal article

Peer reviewed

The roles of plant dsRNA-binding proteins in RNAi-like pathways

Shaun J. Curtin, John M Watson, Neil A. Smith, Andrew Eamens, Chris L. Blanchard and Peter M. Waterhouse

FEBS Letters, Vol.582(18), pp.2753-2760

2008

DOI: https://doi.org/10.1016/j.febslet.2008.07.004

PMID: 18625233

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Abstract

double-stranded RNA

RNA binding protein

RNA interference

gene silencing pathway

Dicers are associated with double-stranded RNA-binding proteins ( dsRBPs) in animals. In the plant, Arabidopsis, there are four dicer-like (DCL) proteins and five potential dsRBPs. These DCLs act redundantly and hierarchically. However, we show there is little or no redundancy or hierarchy amongst the DRBs in their DCL interactions. DCL1 operates exclusively with DRB1 to produce micro (mi) RNAs, DCL4 operates exclusively with DRB4 to produce trans-acting (ta) siRNAs and 21nt siRNAs from viral RNA. DCL2 and DCL3 produce viral siRNAs without requiring assistance from any dsRBP. DRB2, DRB3 and DRB5 appear unnecessary for mi-, tasi-, viral si-, or heterochromatinising siRNA production but act redundantly in a developmental pathway.

Details

Title: The roles of plant dsRNA-binding proteins in RNAi-like pathways
Authors: Shaun J. Curtin (Author) - CSIRO Plant Industry
John M Watson (Author) - CSIRO Plant Industry
Neil A. Smith (Author) - CSIRO Plant Industry
Andrew Eamens (Author) - CSIRO Plant Industry
Chris L. Blanchard (Author) - Charles Sturt University
Peter M. Waterhouse (Author) - CSIRO Plant Industry
Publication details: FEBS Letters, Vol.582(18), pp.2753-2760
Publisher: John Wiley & Sons Ltd
DOI: 10.1016/j.febslet.2008.07.004
ISSN: 1873-3468
PMID: 18625233
Organisation Unit: School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
Language: English
Record Identifier: 99656589502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology

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