The role of vitamin D in adipogenesis

Clare F. Dix; Johanna L. Barcley; Olivia R. L. Wright

doi:10.1093/nutrit/nux056

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Journal article

Peer reviewed

The role of vitamin D in adipogenesis

Clare F. Dix, Johanna L. Barcley and Olivia R. L. Wright

Nutrition Reviews, Vol.76(1), pp.47-59

2018

DOI: https://doi.org/10.1093/nutrit/nux056

PMID: 29244099

Abstract

adipogenesis

adipose tissue

obesity

vitamin D

vitamin D deficiency

Vitamin D, a secosteroid predominately obtained by endogenous production, has in recent years been linked to obesity and its comorbidities. The purpose of this review is to draw conclusions from animal and human studies on the effects of vitamin D on adipogenesis to identify the molecular links between vitamin D and obesity. The information presented herein was obtained from 4 databases (PubMed, CINAHL, Cochrane Library, Scopus) using predefined search terms, as well as research literature and other reviews. The effects of vitamin D on adipogenesis have been researched in several animal models, and the majority of these studies suggest vitamin D plays an inhibitory role in adipogenesis. Studies into vitamin D status and obesity in humans are limited, with the majority being observational epidemiological studies that provide no conclusions on cause and effect or clear links on the molecular mechanisms. The few cell culture and supplementation studies that have investigated adipogenesis in human cells indicate that, in contrast to findings from rodent studies, vitamin D is proadipogenic. There is insufficient evidence to determine whether 1) vitamin D deficiency is associated with a lean or obese phenotype, 2) vitamin D deficiency is a consequence of obesity, or (3) the effects of vitamin D on fat tissue are due to interactions with calcium.

Details

Title: The role of vitamin D in adipogenesis
Authors: Clare F. Dix (Corresponding Author) - University of Queensland
Johanna L. Barcley - Mater Research
Olivia R. L. Wright - University of Queensland
Publication details: Nutrition Reviews, Vol.76(1), pp.47-59
Publisher: Oxford University Press
Date published: 2018
DOI: 10.1093/nutrit/nux056
ISSN: 1753-4887
PMID: 29244099
Organisation Unit: School of Health - Nutrition & Dietetics
Language: English
Record Identifier: 991066743002621
Output Type: Journal article