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The role of left insula in executive set-switching - Lesion evidence from an acute stroke cohort1.20 MB
Published VersionCC BY V4.0, Open Access
Journal article
The role of left insula in executive set-switching: Lesion evidence from an acute stroke cohort
Cortex, Vol.107, pp.92-101
2018
Abstract
Impairments in executive functions are common in stroke survivors, both in the acute and in the chronic phase. However, little is known about the underlying lesion neuroanatomy of these deficits. This study aimed to elucidate the pattern of brain damage underlying executive dysfunction in a large and acute stroke cohort. Executive set-switching deficits were evaluated by a shape-based analogue of the Trail Making Test (from the Oxford Cognitive Screen) in a consecutive sample of 144 stroke patients (age: 70 ± 15 years, examination: 5 ± 4 days post-stroke; brain imaging: 1.7 ± 2.9 days post-stroke). A voxelwise lesion-symptom mapping analysis was performed by combining executive set-switching accuracy scores with manually delineated lesions on computerized tomography or magnetic resonance imaging scans. The analysis showed that lesions within the left insular cortex and adjacent white matter predicted poorer executive set-switching. Further analyses confirmed that the lesion effect in the left insula survived correction for the low-level visuospatial and motor component processes of executive set-switching. In conclusion, the study provides lesion-based evidence for the role of the left insular cortex in flexible switching of attention. The findings are consistent with emergent models of insular function postulating the role of this region in regulatory aspects of goal-directed behaviour.
Details
- Title
- The role of left insula in executive set-switching: Lesion evidence from an acute stroke cohort
- Authors
- Andreja Varjacic (Author) - University of OxfordDante Mantini (Author) - University of OxfordJacob Levenstein (Author) - University of OxfordElitsa D Slavkova (Author) - University of OxfordNele Demeyere (Author) - University of OxfordCeline R Gillebert (Author) - University of Oxford
- Publication details
- Cortex, Vol.107, pp.92-101
- Publisher
- Elsevier BV
- Date published
- 2018
- DOI
- 10.1016/j.cortex.2017.11.009
- ISSN
- 1973-8102; 0010-9452
- Copyright note
- © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99639278802621
- Output Type
- Journal article
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- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- Psychology, Experimental
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