Journal article
The role of T‐cell immunity in COVID‐19 severity amongst people living with type II diabetes
The FEBS Journal, Vol.288(17), pp.5042-5054
2021
PMID: 34216102
Abstract
The COVID-19 pandemic has highlighted the vulnerability of people with diabetes mellitus (DM) to respiratory viral infections. Despite the short history of COVID-19, various studies have shown that patients with DM are more likely to have increased hospitalisation and mortality rates as compared to patients without. At present, the mechanisms underlying this susceptibility are unclear. However, prior studies show that the course of COVID-19 disease is linked to the efficacy of the host’s T-cell responses. Healthy individuals who can elicit a robust T-cell response are more likely to limit the severity of COVID-19. Here, we investigate the hypothesis that an impaired T-cell response in patients with type 2 diabetes mellitus (T2DM) drives the severity of COVID-19 in this patient population. While there is currently a limited amount of information that specifically addresses T-cell responses in COVID-19 patients with T2DM, there is a wealth of evidence from other infectious diseases that T-cell immunity is impaired in patients with T2DM. The reasons for this are likely multifactorial, including the presence of hyperglycaemia, glycaemic variability and metformin use. This review emphasises the need for further research into T-cell responses of COVID-19 patients with T2DM in order to better inform our response to COVID-19 and future disease outbreaks.
Details
- Title
- The role of T‐cell immunity in COVID‐19 severity amongst people living with type II diabetes
- Authors
- Zhen Wei Marcus Tong (Author) - University of QueenslandEmma Grant (Author) - La Trobe University ‐ La Trobe Institute for Molecular Science (LIMS) Melbourne Australia, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University Clayton AustraliaStephanie Gras (Author) - La Trobe University ‐ La Trobe Institute for Molecular Science (LIMS) Melbourne Australia, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University Clayton AustraliaMelanie Wu (Author) - University of QueenslandCorey Smith (Author) - QIMR Berghofer Medical Research InstituteHelen L. Barrett (Author) - Mater Health ServicesLinda A. Gallo (Author) - University of QueenslandKirsty R. Short (Corresponding Author) - University of Queensland
- Publication details
- The FEBS Journal, Vol.288(17), pp.5042-5054
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1111/febs.16105
- ISSN
- 1742-4658
- PMID
- 34216102
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99679194902621
- Output Type
- Journal article
Metrics
9 Record Views
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
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Source: InCites