Journal article
The residual risk of transfusion-transmitted cytomegalovirus infection associated with leucodepleted blood components
Vox Sanguinis, Vol.109(1), pp.11-17
2015
PMID: 25854287
Abstract
Background and Objectives: Cytomegalovirus poses a risk to transfusion safety as its transmission to an immunocompromised recipient may lead to significant clinical sequelae. Once infection is established, it is lifelong and generally asymptomatic. Strategies to reduce the risk of transfusion‐transmitted CMV (TT‐CMV) include donor serological testing and blood component leucodepletion to deplete the transmissible reservoir. We estimate the residual risk for non‐CMV antibody screened, leucodepleted (LD‐only) fresh blood components.
Materials and Methods: We established an approach to estimate the risk of TT‐CMV under various scenarios. We estimated the probability of an infectious component, for both red cells and platelets, as a function of the observed WBC filter failure rate and the probability that such a unit was also contaminated with infectious virus.
Results: Using this model, the estimated combined residual risk of LD‐only red cell and platelet units was very low, 1 in 13 575 000 (95%CI:1 in 1 344 167 000–1 in 1 730 000) as was the individual residual risk estimate for LD‐only red cells, 1 in 7 790 000 (95%CI: 1 in 771 307 000–1 in 993 000) and LD‐only platelets, where a zero risk was estimated (95%CI: 0–1 in 1 074 000).
Conclusion: We describe a novel approach to assess the residual risk of LD‐only components. This can be applied generally using local data. Our risk estimate for LD‐only blood components in Australia is below the threshold of 1 in 1 million, generally considered negligible. This provides a useful indicator of the relative safety of LD‐only components to assist clinical decisions when serologically screened inventory is unavailable.
Details
- Title
- The residual risk of transfusion-transmitted cytomegalovirus infection associated with leucodepleted blood components
- Authors
- Clive Seed (Author) - Australian Red Cross Blood ServiceJ K Wong (Author) - Australian Red Cross Blood ServiceM N Polizzotto (Author) - Monash UniversityHelen Faddy (Author) - Australian Red Cross Blood ServiceA J Keller (Author) - Australian Red Cross Blood ServiceJ Pink (Author) - Australian Red Cross Blood Service
- Publication details
- Vox Sanguinis, Vol.109(1), pp.11-17
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1111/vox.12250
- ISSN
- 1423-0410
- PMID
- 25854287
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; School of Health - Biomedicine; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99477804402621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Hematology
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Source: InCites