Journal article
The relationship between cannabis involvement and suicidal thoughts and behaviors
Drug and Alcohol Dependence, Vol.150, pp.98-104
2015
Abstract
Background: In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology. Methods: We used two community-based twin samples from the Australian Twin Registry, including 9,583 individuals (58.5% female, aged between 27 and 40). The Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) was used to assess cannabis involvement which was categorized into: (0) no cannabis use (reference category); (1) cannabis use only; (2) 1-2 cannabis use disorder symptoms; (3) 3 or more symptoms. Separate multinomial logistic regression analyses were conducted for SI and suicide attempt with or without a plan. Twin analyses examined the genetic overlap between cannabis involvement and SI. Results: All levels of cannabis involvement were related to SI, regardless of duration (Odds ratios [ORs] = 1.28-2.00, p < 0.01). Cannabis use and endorsing ≥3 symptoms were associated with unplanned (SANP; ORs = 1.95 and 2.51 respectively, p < 0.05), but not planned suicide attempts (p > 0.10). Associations persisted even after controlling for other psychiatric disorders and substance involvement. Overlapping genetic (rG = 0.45) and environmental (rE = 0.21) were responsible for the covariance between cannabis involvement and SI. Conclusions: Cannabis involvement is associated, albeit modestly, with SI and unplanned suicide attempts. Such attempts are difficult to prevent and their association with cannabis use and cannabis use disorder symptoms requires further study, including in different samples and with additional attention to confounders.
Details
- Title
- The relationship between cannabis involvement and suicidal thoughts and behaviors
- Authors
- M J Delforterie (Author) - VU University, NetherlandsM Lynskey (Author) - Kings College London, United KingdomA C Huizink (Author) - VU University, NetherlandsH E Creemers (Author) - University of Amsterdam, NetherlandsJ D Grant (Author) - Washington University School of Medicine, United StatesL R Few (Author) - Washington University School of Medicine, United StatesA L Glowinski (Author) - Washington University School of Medicine, United StatesDixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts and BusinessT J Trull (Author) - University of Missouri, United StatesK K Bucholz (Author) - Washington University School of Medicine, United StatesP A F Madden (Author) - Washington University School of Medicine, United StatesN G Martin (Author) - QIMR Berghofer Medical Research InstituteA C Heath (Author) - Washington University School of Medicine, United StatesA Agrawal (Author) - Washington University School of Medicine, United States
- Publication details
- Drug and Alcohol Dependence, Vol.150, pp.98-104
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2015
- DOI
- 10.1016/j.drugalcdep.2015.02.019
- ISSN
- 0376-8716
- Copyright note
- Copyright © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449261102621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
- Substance Abuse
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