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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
The profile of psychiatric symptoms exacerbated by methamphetamine use
Drug and Alcohol Dependence, Vol.161, pp.104-109
2016
PMID: 26874915
Abstract
Background:
Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use.
Methods:
164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis.
Results:
Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ2 (df1) = 3.66, p = 0.056).
Conclusion:
Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome.
Details
- Title
- The profile of psychiatric symptoms exacerbated by methamphetamine use
- Authors
- Rebecca McKetin (Author) - UNSW AustraliaSharon Dawe (Author) - Griffith UniversityRichard A Burns (Author) - Australian National UniversityLeanne Hides (Author) - Queensland University of TechnologyDavid J Kavanagh (Author) - Queensland University of TechnologyMaree Teesson (Author) - UNSW AustraliaRoss Young (Author) - Queensland University of TechnologyAlexandra Voce (Author) - Australian National UniversityJohn B Saunders (Author) - The University of Queensland
- Publication details
- Drug and Alcohol Dependence, Vol.161, pp.104-109
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2016
- DOI
- 10.1016/j.drugalcdep.2016.01.018
- ISSN
- 1879-0046; 0376-8716
- PMID
- 26874915
- Copyright note
- Copyright © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551607102621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Psychiatry
- Substance Abuse
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