The photoreactivity of ocular lipofuscin

M Boulton; M Rózanowska; B Rözanowski; Tim J Wess

doi:10.1039/b400108g

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The photoreactivity of ocular lipofuscin

Journal article

Peer reviewed

The photoreactivity of ocular lipofuscin

M Boulton, M Rózanowska, B Rözanowski and Tim J Wess

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Vol.3(8), pp.759-764

2004

DOI: https://doi.org/10.1039/b400108g

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Abstract

Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss. © The Royal Society of Chemistry of Owner Societies 2004.

Details

Title: The photoreactivity of ocular lipofuscin
Authors: M Boulton (Author) - Cardiff University, United Kingdom
M Rózanowska (Author) - Cardiff University, United Kingdom
B Rözanowski (Author) - Cardiff University, United Kingdom
Tim J Wess (Author) - Cardiff University, United Kingdom
Publication details: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Vol.3(8), pp.759-764
Publisher: Royal Society of Chemistry (R S C) Publications
Date published: 2004
DOI: 10.1039/b400108g
ISSN: 1474-905X
Organisation Unit: Office of the Deputy Vice-Chancellor (Academic); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450749802621
Output Type: Journal article

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