The missing hydrogen ion, part-2: Where the evidence leads to

Robert A Robergs; Bridgette O'Malley; Sam Torrens; Jason Siegler

doi:10.1016/j.smhs.2024.01.001

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The missing hydrogen ion, part-2: Where the evidence leads to

Journal article

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Peer reviewed

The missing hydrogen ion, part-2: Where the evidence leads to

Robert A Robergs, Bridgette O'Malley, Sam Torrens and Jason Siegler

Sports Medicine and Health Science, Vol.6(1), pp.94-100

2024

DOI: https://doi.org/10.1016/j.smhs.2024.01.001

PMID: 38463661

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Abstract

metabolic biochemistry

acidosis

carboxyl

phosphoryl

metabolic acid

dissociation

association

The purpose of this manuscript was to present the evidence for why cells do not produce metabolic acids. In addition, evidence that opposes common viewpoints and arguments used to support the cellular production of lactic acid (HLa) or liver keto-acids have been provided. Organic chemistry reveals that many molecules involved in cellular energy catabolism contain functional groups classified as acids. The two main acidic functional groups of these molecules susceptible to _H+ release are the carboxyl and phosphoryl structures, though the biochemistry and organic chemistry of molecules having these structures reveal they are produced in a non -acidic ionic (negatively charged) structure, thereby preventing pH dependent _H+ release. Added evidence from the industrial production of HLa further reveals that lactate (La-) is produced followed by an acidification step that converts La- to HLa due to pH dependent _H+ association. Interestingly, there is a plentiful list of other molecules that are classified as acids and compared to HLa have similar values for their H+ dissociation constant (pKd). For many metabolic conditions, the cumulative turnover of these molecules is far higher than for La-. The collective evidence documents the non -empirical basis for the construct of the cellular production of HLa, or any other metabolic acid.

Details

Title: The missing hydrogen ion, part-2: Where the evidence leads to
Authors: Robert A Robergs (Corresponding Author) - Queensland University of Technology
Bridgette O'Malley - Queensland University of Technology
Sam Torrens - Queensland University of Technology
Jason Siegler - Arizona State University
Publication details: Sports Medicine and Health Science, Vol.6(1), pp.94-100
Publisher: KeAi Publishing Communications Ltd.
Date published: 2024
DOI: 10.1016/j.smhs.2024.01.001
ISSN: 2666-3376
PMID: 38463661
Copyright note: © 2024 Chengdu Sport University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Organisation Unit: School of Health - Biomedicine; School of Health - Sports & Exercise Science
Language: English
Record Identifier: 991156939702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Sport Sciences