The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response

Katrina Morris; Peter Prentis; Denis O'Meally; Ana Pavasovic; Alyce Taylor-Brown; Peter Timms; Katherine Belov; Adam Polkinghorne

doi:10.1071/ZO13105

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The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response

Journal article

Peer reviewed

The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response

Katrina Morris, Peter Prentis, Denis O'Meally, Ana Pavasovic, Alyce Taylor-Brown, Peter Timms, Katherine Belov and Adam Polkinghorne

Australian Journal of Zoology, Vol.62(3), pp.195-199

2014

DOI: https://doi.org/10.1071/ZO13105

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Abstract

koala

Chlamydia

The koala (Phascolarctos cinereus) is an Australian marsupial that continues to experience significant population declines. Infectious diseases caused by pathogens such as Chlamydia are proposed to have a major role. Very few species-specific immunological reagents are available, severely hindering our ability to respond to the threat of infectious diseases in the koala. In this study, we utilise data from the sequencing of the koala transcriptome to identify key immunological markers of the koala adaptive immune response and cytokines known to be important in the host response to chlamydial infection in other species. This report describes the identification and preliminary sequence analysis of (i) T lymphocyte glycoprotein markers (CD4, CD8); (ii) IL-4, a marker for the Th2 response; (iv) cytokines such as IL-6, IL-12 and IL-1ÃŽÂ², that have been shown to have a role in chlamydial clearance and pathology in other hosts and; (v) the sequences for the koala immunoglobulins, IgA, IgG, IgE and IgM. These sequences will enable the development of a range of immunological reagents for understanding the koala innate and adaptive immune responses, while also providing a resource that will enable continued investigations into the origin and evolution of the marsupial immune system.

Details

Title: The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response
Authors: Katrina Morris (Author) - University of Sydney
Peter Prentis (Author) - Queensland University of Technology
Denis O'Meally (Author) - University of Sydney
Ana Pavasovic (Author) - Queensland University of Technology
Alyce Taylor-Brown (Author) - Queensland University of Technology
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Katherine Belov (Author) - University of Sydney
Adam Polkinghorne (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Australian Journal of Zoology, Vol.62(3), pp.195-199
Publisher: C S I R O Publishing
Date published: 2014
DOI: 10.1071/ZO13105
ISSN: 0004-959X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448861102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Zoology

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