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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors
Journal of Optometry, Vol.15(2), pp.112-121
2022
PMID: 33402286
Abstract
Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults with various refractive errors using a custom-made optical system. Methods: PIPR was measured on myopic (-3.50 +/- 1.82 D, n = 20) and non-myopic (+0.28 +/- 0.23 D, n = 19) participants (mean age, 23.36 +/- 3.06 years). The right eye was dilated and presented with long-wavelength (red, 625 nm, 3.68 x 10(14) photons/cm2/s) and short-wavelength (blue, 470 nm, 3.24 x 10(14) photons/cm(2)/s) 1 s and 5 s pulses of light, and the consensual response was measured in the left eye for 60 s following light offset. The 6 s and 30 s PIPR and early and late area under the curve (AUC) for 1 and 5 s stimuli were calculated. Results: For most subjects, the 6 s and 30 s PIPR were significantly lower (p < 0.001), and the early and late AUC were significantly larger for 1 s blue light compared to red light (p < 0.001), suggesting a strong ipRGC response. The 5 s blue stimulation induced a slightly stronger melanopsin response, compared to 1 s stimulation with the same wavelength. However, none of the PIPR metrics were different between myopes and non-myopes for either stimulus duration (p > 0.05). Conclusions: We confirm previous research that there is no effect of refractive error on the PIPR. (c) 2020 Spanish General Council of Optometry. Published by Elsevier Espana, S.L.U.
Details
- Title
- The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors
- Authors
- Ranjay Chakraborty (Corresponding Author) - Flinders UniversityMichael J. Collins (Author) - Queensland University of TechnologyHenry Kricancic (Author) - Queensland University of TechnologyDaniel Moderiano (Author) - Flinders UniversityBrett Davis (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyFan Yi (Author) - Queensland University of TechnologyKarthikeyan Baskaran (Author) - Linnaeus University
- Publication details
- Journal of Optometry, Vol.15(2), pp.112-121
- Publisher
- Colegio Nacional de Opticos Optometristas de Espana,Spanish Council of Optometry
- Date published
- 2022
- DOI
- 10.1016/j.optom.2020.12.001
- ISSN
- 1989-1342; 1888-4296
- PMID
- 33402286
- Copyright note
- © 2020 Spanish General Council of Optometry. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Grant note
- This work was supported by the Flinders University College of Nursing and Health Sciences Establishment Grant [01.529.41820]; and the Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Australia.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973595302621
- Output Type
- Journal article
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