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Published VersionCC BY V4.0, Open Access
Journal article
The instrumental role of lipids in governing the sensitivity of multiple myeloma to ferroptosis
Discover Oncology, Vol.16(1), pp.1-18
2025
PMID: 40853521
Appears in Cancer Research Cluster Research Collection
Abstract
Multiple myeloma (MM) is a malignancy characterised by the uncontrolled proliferation of clonal plasma cells, primarily within the bone marrow, and is still considered incurable. A significant proportion of patients relapse with drug-refractory disease, necessitating the development of novel therapeutic approaches. Ferroptosis is a recently-characterised form of non-apoptotic programmed cell death, linked to phospholipid peroxidation, that represents a promising approach for the treatment of MM and other cancers, that are refractory to more conventional apoptosis-inducing regimens. A better understanding of the relationship between cellular lipid composition and ferroptosis sensitivity is key to harnessing this form of programmed cell death as a therapeutic approach. In addition to the cellular proportions of phospholipids containing poly- and monounsaturated fatty acids, studies to date indicate that cholesterol levels impact not only the onset and progression of haematological malignancies but also the sensitivity of a variety of different cancers to ferroptosis. Therefore, manipulating the uptake and metabolism of lipids, including glycerophospholipids and cholesterol, may be an effective means of sensitising MM cells to ferroptosis. Findings from the limited number of studies concerning ferroptosis in MM and compelling evidence from other malignancies, provide a strong rationale for further investigation of ferroptosis as a novel therapeutic approach for MM.
Details
- Title
- The instrumental role of lipids in governing the sensitivity of multiple myeloma to ferroptosis
- Authors
- Ali Habib (Author) - Flinders UniversityOliver G Best (Author) - Flinders UniversityCharlotte E Toomes (Author) - Flinders UniversityCraig Wallington-Gates (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health
- Publication details
- Discover Oncology, Vol.16(1), pp.1-18
- Publisher
- Springer Cham
- Date published
- 2025
- DOI
- 10.1007/s12672-025-03444-9
- ISSN
- 2730-6011
- PMID
- 40853521
- Copyright note
- © Crown 2025. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Data Availability
- No datasets were generated or analysed during the current study.
- Grant note
- A.H. was funded by a Jane Watson Ramsey Myeloma Research PhD Scholarship. C.W.G was funded by a Cancer Council SA Clinical Investigator Grant and Flinders Foundation Cancer Seed Grant.
- Organisation Unit
- School of Health; Cancer Research Cluster
- Language
- English
- Record Identifier
- 991162645102621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Oncology
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