Journal article
The insecticidal potential of venom peptides
Cellular and Molecular Life Sciences, Vol.70(19), pp.3665-3693
2013
Abstract
Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical insecticides are currently the dominant approach for combating these pests. However, the de-registration of key classes of chemical insecticides due to their perceived ecological and human health risks in combination with the development of insecticide resistance in many pest insect populations has created an urgent need for improved methods of insect pest control. The venoms of arthropod predators such as spiders and scorpions are a promising source of novel insecticidal peptides that often have different modes of action to extant chemical insecticides. These peptides have been optimized via a prey-predator arms race spanning hundreds of millions of years to target specific types of insect ion channels and receptors. Here we review the current literature on insecticidal venom peptides, with a particular focus on their structural and pharmacological diversity, and discuss their potential for deployment as insecticides.
Details
- Title
- The insecticidal potential of venom peptides
- Authors
- J J Smith (Author) - University of QueenslandVolker Herzig (Author) - University of QueenslandG F King (Author) - University of QueenslandP F Alewood (Author) - University of Queensland
- Publication details
- Cellular and Molecular Life Sciences, Vol.70(19), pp.3665-3693
- Publisher
- Birkhaeuser Science
- Date published
- 2013
- DOI
- 10.1007/s00018-013-1315-3
- ISSN
- 1420-682X
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450815102621
- Output Type
- Journal article
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