The influence of fetal sex on antenatal maternal glucose and insulin dynamics

Thomas P. Mullins; Linda A. Gallo; H. David McIntyre; Helen L. Barrett

doi:10.3389/fcdhc.2024.1351317

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The influence of fetal sex on antenatal maternal glucose and insulin dynamics

Journal article

Open access

Peer reviewed

The influence of fetal sex on antenatal maternal glucose and insulin dynamics

Thomas P. Mullins, Linda A. Gallo, H. David McIntyre and Helen L. Barrett

Frontiers in Clinical Diabetes and Healthcare, Vol.5, pp.1-8

2024

DOI: https://doi.org/10.3389/fcdhc.2024.1351317

PMCID: PMC11685148

PMID: 39742292

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Abstract

gestational diabetes mellitus

fetal sex

maternal metabolism

mechanism

glucose

insulin

The ‘Developmental Origins of Health and Disease’ (DOHaD) hypothesis postulates that exposures during critical periods of development and growth, including maternal hyperglycemia, can have significant consequences for short- and long-term health in offspring. The influence of fetal status on maternal (patho)physiology is less well understood but gaining attention. Fetal sex specifically may be an independent risk factor for a range of adverse pregnancy outcomes, including increased gestational diabetes mellitus (GDM) frequency with male fetuses in multi-ethnic populations. Fetal sex has been thought to modulate maternal glucose metabolism, including insulin dynamics, through complex genetic and hormonal interactions. Mechanisms have not been fully elucidated, however, but may relate to sexual dimorphism in maternal-fetal-placental interactions. We review current evidence on the potential influence of fetal sex on maternal glucose and insulin dynamics, and fetal outcomes.

Details

Title: The influence of fetal sex on antenatal maternal glucose and insulin dynamics
Authors: Thomas P. Mullins (Corresponding Author) - The University of Queensland
Linda A. Gallo - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
H. David McIntyre - Mater Health Services
Helen L. Barrett - UNSW Sydney
Publication details: Frontiers in Clinical Diabetes and Healthcare, Vol.5, pp.1-8
Publisher: Frontiers Research Foundation
Date published: 2024
DOI: 10.3389/fcdhc.2024.1351317
ISSN: 2673-6616
PMID: 39742292; PMC11685148
Copyright note: © 2024 Mullins, Gallo, McIntyre and Barrett. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Grant note: The University of Queensland, and the Mater Foundation for institutional support. TM is supported by the Australian Postgraduate Award and Frank Clair Scholarship.
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991091094702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Endocrinology & Metabolism

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