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The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans838.07 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans
Psychiatry Research, Vol.270, pp.775-779
2018
PMID: 30551324
Abstract
Several studies have established that Major depressive disorder is associated with excess inflammation with an elevation of both pro and anti-inflammatory cytokines in major depressive disorder. In addition, individuals with major depressive disorder are at higher risk of developing coronary artery disease. The role of innate immunity and NFκB-mediated inflammation in depression and its increased association with coronary artery disease is yet to be fully elucidated. Polymorphisms in the Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat and Pyrin Domain Containing 12 (NLRP12), are associated with depression and coronary artery disease in trauma exposed individuals.
In a cohort of Vietnam War veterans (n = 299) NLRP12 polymorphisms were analysed for association with depression and coronary calcium scores. The NLRP12 polymorphism, rs34436714 was associated with a higher DASS21 Score for depression (p = 0.037). NLRP12 polymorphisms rs34971363 and rs6509825 (p = 0.022 and p = 0.020) were associated with raised coronary calcium score. To our knowledge, this is the first time rs34436714 has been investigated in Vietnam veterans identifying AC as a risk genotype for depression in Caucasian cohorts. It is also the first time the rs34971363 (CG) and rs6509825 (CT) genotype have been associated with raised coronary calcium score.
Details
- Title
- The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans
- Authors
- Wole Akosile (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of TechnologyBruce Lawford (Author) - Queensland University of TechnologyDavid Colquhoun (Author) - Greenslopes Private HospitalRoss Young (Author) - Greenslopes Private HospitalDivya Mehta (Author) - Queensland University of Technology
- Publication details
- Psychiatry Research, Vol.270, pp.775-779
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2018
- DOI
- 10.1016/j.psychres.2018.10.051
- ISSN
- 1872-7123; 0165-1781
- PMID
- 30551324
- Copyright note
- Copyright © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550994602621
- Output Type
- Journal article
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- Psychiatry
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