Journal article
The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit
Bioorganic & Medicinal Chemistry Letters, Vol.5(16), pp.1869-1874
1995
Abstract
The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit. © 1995.
Details
- Title
- The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit
- Authors
- Rodney H White (Author) - Griffith UniversityP G Parsons (Author) - Queensland Institute of Medical ResearchA S Prakash (Author) - National Research Centre for Environmental ToxicologyDavid James Young (Author) - Griffith University
- Publication details
- Bioorganic & Medicinal Chemistry Letters, Vol.5(16), pp.1869-1874
- Publisher
- Pergamon
- Date published
- 1995
- DOI
- 10.1016/0960-894X(95)00310-P
- ISSN
- 0960-894X
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449302602621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic
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Source: InCites