The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S C Ng; P G Parsons; K Y Sim; C J Tranter; Rodney H White; David James Young

doi:10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

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The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

Journal article

Peer reviewed

The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

S C Ng, P G Parsons, K Y Sim, C J Tranter, Rodney H White and David James Young

Applied Organometallic Chemistry, Vol.11(7), pp.577-581

1997

DOI: https://doi.org/10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S

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Abstract

antitumour

dioxastannolanes

human cell lines

Six dibutyl-l,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide. © 1997 by John Wiley & Sons, Ltd.

Details

Title: The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes
Authors: S C Ng (Author) - National University of Singapore, Singapore
P G Parsons (Author) - Queensland Institute of Medical Research
K Y Sim (Author) - National University of Singapore, Singapore
C J Tranter (Author) - Griffith University
Rodney H White (Author) - Griffith University
David James Young (Author) - Griffith University
Publication details: Applied Organometallic Chemistry, Vol.11(7), pp.577-581
Publisher: John Wiley & Sons Ltd.
Date published: 1997
DOI: 10.1002/(SICI)1099-0739(199707)11:7<577::AID-AOC612>3.0.CO;2-S
ISSN: 0268-2605
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449831802621
Output Type: Journal article

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Web Of Science research areas: Chemistry, Applied; Chemistry, Inorganic & Nuclear

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