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Published VersionCC BY V4.0, Open Access
Journal article
The importance of glycogen molecular structure for blood glucose control
iScience, Vol.24(1), pp.1-12
2021
PMID: 33458612
Abstract
Type 2 diabetes incidence continues to increase rapidly. This disease is characterized by a breakdown in blood glucose homeostasis. The impairment of glycemic control is linked to the structure of glycogen, a highly branched glucose polymer. Liver glycogen, a major controller of blood sugar, comprises small beta particles which can link together to form larger alpha particles. These degrade to glucose more slowly than beta particles, enabling a controlled release of blood glucose. The alpha particles in diabetic mice are however easily broken down into beta particles, which degrade more quickly. Because this may lead to higher blood glucose, understanding this diabetes-associated breakdown of alpha-particle molecular structure may help in the development of diabetes therapeutics. We review the extraction of liver glycogen, its molecular structure, and how this structure is affected by diabetes and then use this knowledge to make postulates to guide the development of strategies to help mitigate type 2 diabetes.
Details
- Title
- The importance of glycogen molecular structure for blood glucose control
- Authors
- Asad Nawaz - Yangzhou UniversityPeng Zhang - Yangtze Normal UniversityEnpeng Li - Yangzhou UniversityRobert G Gilbert (Corresponding Author) - The University of QueenslandMitchell A Sullivan (Corresponding Author) - The University of Queensland
- Publication details
- iScience, Vol.24(1), pp.1-12
- Publisher
- Cell Press
- Date published
- 2021
- DOI
- 10.1016/j.isci.2020.101953
- ISSN
- 2589-0042
- PMID
- 33458612
- Copyright note
- (c) 2020 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035095002621
- Output Type
- Journal article
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