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Journal article
The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review
Pathology, Vol.56(5), pp.619-632
2024
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Abstract
Deaths from non-melanoma skin cancers (NMSCs) have almost doubled in Australia in recent years. Cutaneous squamous cell carcinoma (cSCC) constitutes approximately 20% of NMSCs but is responsible for most of the deaths. Most skin cancers are easy to diagnose and treat and therefore cSCC are often trivialised; however, there is a high-risk subgroup of cSCC (HRcSCC) that is associated with a high risk of metastasis and death. The definition of early HRcSCC and our ability to identify them is still evolving. Many significant prognostic factors have been identified, but a universally accepted prognostic index does not exist. Guidelines for workup, treatment, and follow-up leave many important decisions open to broad interpretation by the treating physician or multidisciplinary team. Some of the treatments used for metastatic cSCC are not supported by robust evidence and the prognosis of metastatic cSCC is guarded. In this review, we highlight the rapid rise in NMSC deaths and discuss some of the deficiencies in our knowledge of how to define, diagnose, stage, and manage HRcSCC.
Details
- Title
- The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review
- Authors
- Andrew Dettrick (Corresponding Author) - University of the Sunshine CoastNeil Foden - Sunshine Coast University HospitalDavid Hogan - Sunshine Coast University HospitalMary Azer - Sunshine Coast University HospitalJohn Blazak - Sunshine Coast University HospitalDaisy Atwell - Sunshine Coast University HospitalNicole Buddle - Sunshine Coast University HospitalMyo Min - University of the Sunshine Coast, Queensland, Thompson InstituteRyan Livingston - Plastic Surgery, Sunshine Coast University Hospital, Sunshine Coast, Qld, AustraliaLeith Banney - Sunshine Coast University HospitalRebecca Donkin - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
- Publication details
- Pathology, Vol.56(5), pp.619-632
- Publisher
- Elsevier Ltd
- Date published
- 2024
- DOI
- 10.1016/j.pathol.2024.05.002
- ISSN
- 1465-3931
- Copyright note
- © 2024 The Author(s). Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine; School of Health; Thompson Institute; Cancer Research Cluster; External
- Language
- English
- Record Identifier
- 991034898702621
- Output Type
- Journal article
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