The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review

Andrew Dettrick; Neil Foden; David Hogan; Mary Azer; John Blazak; Daisy Atwell; Nicole Buddle; Myo Min; Ryan Livingston; Leith Banney; Rebecca Donkin

doi:10.1016/j.pathol.2024.05.002

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The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review

Journal article

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The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review

Andrew Dettrick, Neil Foden, David Hogan, Mary Azer, John Blazak, Daisy Atwell, Nicole Buddle, Myo Min, Ryan Livingston, Leith Banney, …

Pathology, Vol.56(5), pp.619-632

2024

DOI: https://doi.org/10.1016/j.pathol.2024.05.002

PMID: 38871593

Appears in UniSC Supported Open Access Outputs

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Research uncovers hidden Australian skin cancer epidemic

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Abstract

Carcinoma

histopathology

skin neoplasms

squamous cell

squamous cell carcinoma

Deaths from non-melanoma skin cancers (NMSCs) have almost doubled in Australia in recent years. Cutaneous squamous cell carcinoma (cSCC) constitutes approximately 20% of NMSCs but is responsible for most of the deaths. Most skin cancers are easy to diagnose and treat and therefore cSCC are often trivialised; however, there is a high-risk subgroup of cSCC (HRcSCC) that is associated with a high risk of metastasis and death. The definition of early HRcSCC and our ability to identify them is still evolving. Many significant prognostic factors have been identified, but a universally accepted prognostic index does not exist. Guidelines for workup, treatment, and follow-up leave many important decisions open to broad interpretation by the treating physician or multidisciplinary team. Some of the treatments used for metastatic cSCC are not supported by robust evidence and the prognosis of metastatic cSCC is guarded. In this review, we highlight the rapid rise in NMSC deaths and discuss some of the deficiencies in our knowledge of how to define, diagnose, stage, and manage HRcSCC.

Details

Title: The hidden Australian skin cancer epidemic, high-risk cutaneous squamous cell carcinoma: a narrative review
Authors: Andrew Dettrick (Corresponding Author) - University of the Sunshine Coast
Neil Foden - Sunshine Coast University Hospital
David Hogan - Sunshine Coast University Hospital
Mary Azer - Sunshine Coast University Hospital
John Blazak - Sunshine Coast University Hospital
Daisy Atwell - Sunshine Coast University Hospital
Nicole Buddle - Sunshine Coast University Hospital
Myo Min - University of the Sunshine Coast, Queensland, Thompson Institute
Ryan Livingston - Plastic Surgery, Sunshine Coast University Hospital, Sunshine Coast, Qld, Australia
Leith Banney - Sunshine Coast University Hospital
Rebecca Donkin - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Publication details: Pathology, Vol.56(5), pp.619-632
Publisher: Elsevier Ltd
Date published: 2024
DOI: 10.1016/j.pathol.2024.05.002
ISSN: 1465-3931
PMID: 38871593
Copyright note: © 2024 The Author(s). Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health - Biomedicine; School of Health; Thompson Institute; Cancer Research Cluster; External
Language: English
Record Identifier: 991034898702621
Output Type: Journal article

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