Journal article
The first two cantharidin analogues displaying PP1 selectivity
Bioorganic & Medicinal Chemistry Letters, Vol.12(3), pp.391-393
2002
Abstract
High pressure Diels-Alder reactions of furan and dimethylmaleate, and thiophene and maleimide resulted in two cantharidin analogues, 3 and 6 possessing PP1 selectivity (>40- and >30-fold selectivity) over PP2A. Both compounds exhibited moderate PP1 activity, 3 IC50 50 μM and 6 IC50 12.5 μM. Interestingly, the corresponding mono-ester derivatives of 3 showed no such selectivity. © 2002 Elsevier Science Ltd. All rights reserved.
Details
- Title
- The first two cantharidin analogues displaying PP1 selectivity
- Authors
- A McCluskey (Author) - University of NewcastleM A Keane (Author) - University of NewcastleC C Walkom (Author) - University of NewcastleM C Bowyer (Author) - University of NewcastleA T R Sim (Author) - University of NewcastleDavid James Young (Author) - Griffith UniversityJ A Sakoff (Author) - Newcastle Mater Misericordiae Hospital
- Publication details
- Bioorganic & Medicinal Chemistry Letters, Vol.12(3), pp.391-393
- Publisher
- Pergamon
- Date published
- 2002
- DOI
- 10.1016/S0960-894X(01)00777-6
- ISSN
- 0960-894X
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450179002621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic
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Source: InCites