The effects of prolonged acute hypobaric hypoxia on novel measures of biventricular performance

C J Boos; P D Hodkinson; A Mellor; N P Green; D Bradley; Kim Greaves; D R Woods

doi:10.1111/echo.12088

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The effects of prolonged acute hypobaric hypoxia on novel measures of biventricular performance

Journal article

Peer reviewed

The effects of prolonged acute hypobaric hypoxia on novel measures of biventricular performance

C J Boos, P D Hodkinson, A Mellor, N P Green, D Bradley, Kim Greaves and D R Woods

Echocardiography, Vol.30(5), pp.534-541

2013

DOI: https://doi.org/10.1111/echo.12088

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Abstract

hypobaric hypoxia

echocardiography

EAS index

biventricular function

pulmonary arterysystolic pressure

Background There are limited data on the effects of prolonged acute hypoxia on individual and global measures of biventricular function. Aims The aim of this study was to assess its effects on conventional and novel measures of biventricular function, including the recently defined E?/ (A?×S?) (EAS) index, obtained using pulsed-wave tissue Doppler Imaging (PWTDI) and associated blood brain natriuretic peptide (BNP) levels. Methods In this study, 14 healthy subjects aged 30.5 years were assessed at baseline and at >150 minutes following hypobaric hypoxia (HH) to the equivalent altitude of 4800 m for a total of 180 minutes. The combined EAS index (E?/(A? × S?)) was calculated at the mitral and tricuspid annulus using data from the peak systolic (S?) early (E?) and late (A?) diastolic filling. Results It was seen that HH increased resting heart rate (63.4±8.4 vs. 85.2±10.2/min; P < 0.0001), cardiac output (4.6±0.7 L/min vs. 6.1±1.2 L/min; P < 0.0001), peak pulmonary artery systolic pressure (PASP) (26.3±2.0 mmHg vs. 37.2±6.3 mmHg; P < 0.0001), and reduced SpO2 (98.5±1.1 vs. 72.9±8.1%; P < 0.0001). There was a significant reduction in mitral (0.19±0.06 vs. 0.11±0.03; P < 0.0001) and tricuspid (0.12±0.04 vs. 0.09±0.03; P = 0.03) EAS indices, but no change in left or right ventricular myocardial performance (Tei) indices, global left ventricular (LV) longitudinal systolic strain, BNP levels, or estimated filling pressures (E/E?). Only reducing SpO 2 remained as an independent predictor of PASP on multivariate analysis (overall R2 = 0.77; P < 0.0001). The right and LV EAS indices were significantly correlated (r = 0.45; 95% CI: 0.07-0.7; P = 0.02). Conclusion The conclusion from this study was that acute prolonged HH does not adversely affect resting global biventricular function and there is evidence of linked right and LV responses. © 2013, Wiley Periodicals, Inc.

Details

Title: The effects of prolonged acute hypobaric hypoxia on novel measures of biventricular performance
Authors: C J Boos (Author) - Poole Hospital, United Kingdom
P D Hodkinson (Author) - RAF Centre of Aviation Medicine, United Kingdom
A Mellor (Author) - Poole Hospital, United Kingdom
N P Green (Author) - James Cook University Hospital, United Kingdom
D Bradley (Author) - GE Healthcare, United Kingdom
Kim Greaves (Author) - Bournemouth University, United Kingdom
D R Woods (Author) - University of Newcastle, United Kingdom
Publication details: Echocardiography, Vol.30(5), pp.534-541
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2013
DOI: 10.1111/echo.12088
ISSN: 0742-2822
Organisation Unit: Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449116902621
Output Type: Journal article

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Web Of Science research areas: Cardiac & Cardiovascular Systems

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