The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial

Kate E Devenney; Brian Lawlor; Marcel G M Olde Rikkert; Stefan Schneider

doi:10.1186/s12877-017-0457-9

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The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial

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The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial

Kate E Devenney, Brian Lawlor, Marcel G M Olde Rikkert and Stefan Schneider

BMC Geriatrics, Vol.17, 75

2017

DOI: https://doi.org/10.1186/s12877-017-0457-9

PMCID: PMC5361785

PMID: 28330458

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

mild cognitive impairment

exercise intervention

physical activity

cognitive function

brain structure

frailty

epigenetics

UniSC Diversity Area - Disability and Inclusion

Background: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI. This study aims to determine the effects of an extensive exercise programme on the progression of MCI. Methods/design: This randomised controlled clinical intervention study will take place across three European sites. Seventy-five previously sedentary patients with a clinical diagnosis of MCI will be recruited at each site. Participants will be randomised to one of three groups. One group will receive a standardised 1-year extensive aerobic exercise intervention (3 units of 45 min/week). The second group will complete stretching and toning (non-aerobic) exercise (3 units of 45 min/week) and the third group will act as the control group. Change in all outcomes will be measured at baseline (T0), after six months (T1) and after 12 months (T2). The primary outcome, cognitive performance, will be determined by a neuropsychological test battery (CogState battery, Trail Making Test and Verbal fluency). Secondary outcomes include Montreal Cognitive Assessment (MoCA), cardiovascular fitness, physical activity, structural changes of the brain, quality of life measures and measures of frailty. Furthermore, outcome variables will be related to genetic variations on genes related to neurogenesis and epigenetic changes in these genes caused by the exercise intervention programme. Discussion: The results will add new insights into the prevailing notion that exercise may slow the rate of cognitive decline in MCI.

Details

Title: The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial
Authors: Kate E Devenney (Author) - Trinity College, Ireland
Brian Lawlor (Author) - Trinity College, Ireland
Marcel G M Olde Rikkert (Author) - Radboud University Medical Centre, Netherlands
Stefan Schneider (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: BMC Geriatrics, Vol.17, 75; 10
Publisher: BioMed Central Ltd.
Date published: 2017
DOI: 10.1186/s12877-017-0457-9
ISSN: 1471-2318
PMID: 28330458; PMC5361785
Copyright note: Copyright © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99451174502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Geriatrics & Gerontology; Gerontology

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